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Gelsolin

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[[Image:3ffn.jpg|left|200px]]
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<StructureSection load='1h1v' size='350' side='right' caption='Human gelsolin S4-S6 (gold) complex with actin (cyan), ATP and Ca+2 ion (green) (PDB entry [[1h1v]])' scene='41/410297/Cv/3'>
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<!--
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__TOC__
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{{Structure
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== Function ==
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|PDB=3ffn|SIZE=350|SCENE=|CAPTION=Gelsolin (GLS), 3FFN
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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|RELATEDENTRY=
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|RESOURCES=
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}}
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-->
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{{STRUCTURE_3ffn| PDB=3ffn | SCENE=Gelsolin/Cv/1 |CAPTION=Gelsolin (GLS), [[3ffn]] }}
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'''3D Structure of Gelsolin''' <br />
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[[Gelsolin]] (GLS) is a protein regulator of actin assembly and disassembly<ref>PMID:10559185</ref>. Binding of Ca+2 ion to GLS induces conformational change which enables it to bind actin.
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== Structural highlights ==
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== Actin Binding Protein ==
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GLS contains 6 homologous domains S1 to S6. The human GLS domains span residues: 15-135, 136-248, 249-367, 394-513, 514-619 and 620-734. <scene name='41/410297/Cv/6'>S4-S6 are shown</scene>. The <scene name='41/410297/Cv/7'>binding site of Ca+2 ion includes Glu, Asp and 2 carbonyl oxygens</scene><ref>PMID:12460571</ref>.
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Gelsolin (GLS) is a protein regulator of actin assembly and disassembly. It contains 6 homologous domains S1 to S6. The image at the right is a <scene name='Gelsolin/Cv/2'>dimer</scene> of the Gelsolin
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== 3D Structures of gelsolin ==
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[[Gelsolin 3D structures]]
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== 3D Structures of GLS ==
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</StructureSection>
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== References ==
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=== GLS ===
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<references/>
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[[Category:Topic Page]]
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[[3ffn]] – hGLS – human <br />
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[[2fgh]] – hoGLS+ATP – horse <br />
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[[1d0n]] - hoGLS <br />
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=== GLS domains S1-S3 ===
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[[3ffk]] – hGLS domains S1-S3+actin <br />
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[[1rgi]] - hoGLS domains S1-S3+actin <br />
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=== GLS domains S4-S6 ===
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[[1h1v]] - hGLS domains S4-S6+actin<br />
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[[1nph]] - GLS domains S4-S6+Ca – mouse<br />
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=== GLS domain S1 ===
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[[2ff3]] - hGLS domain S1+N-WASP+actin<br />
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[[2ff6]] - hGLS domain S1+Ciboulot domain 2+actin<br />
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[[1mdu]] - hGLS domain S1+chActin – chicken<br />
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[[1d4x]] - hGLS domain S1+CeActin+Mg-ATP – ''Caenorhabditis elegans''<br />
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[[1esv]] - hGLS domain S1+rActin+latrunculin – rabbit<br />
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[[1eqy]] - hGLS domain S1+rActin<br />
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[[1yvn]] - hGLS domain S1+yActin (mutant) – yeast<br />
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[[1yag]] - hGLS domain S1+yActin<br />
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[[1kcq]] – hGLS domainS1+Cd<br />
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[[1c0f]] - hGLS domain S1+DdActin+Ca-ATP - ''Dictyostelium discoideum''<br />
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[[1c0g]], [[1dej]] - hGLS domain S1+DdActin (mutant)<br />
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[[3ci5]], [[3cip]], [[1nlv]] – DdGLS domain S1+actin<br />
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[[1nm1]] - DdGLS domain S1+actin+Mg-ATP<br />
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[[3cjb]] - rGLS domain S1+rActin<br />
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[[3cjc]] - rGLS domain S1+rActin+DNAse I<br />
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[[1nmd]] - hGLS domain S1+actin+Ca+ATP<br />
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=== GLS C-terminal ===
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[[2fh1]], [[2fh2]], [[2fh3]], [[2fh4]] – hGLS C-terminal<br />
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[[1p8x]] - hGLS C-terminal+Ca<br />
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[[1p8z]] – hGLS fraction+rActin<br />
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Current revision

Human gelsolin S4-S6 (gold) complex with actin (cyan), ATP and Ca+2 ion (green) (PDB entry 1h1v)

Drag the structure with the mouse to rotate

References

  1. ↑ Sun HQ, Yamamoto M, Mejillano M, Yin HL. Gelsolin, a multifunctional actin regulatory protein. J Biol Chem. 1999 Nov 19;274(47):33179-82. PMID:10559185
  2. ↑ Choe H, Burtnick LD, Mejillano M, Yin HL, Robinson RC, Choe S. The calcium activation of gelsolin: insights from the 3A structure of the G4-G6/actin complex. J Mol Biol. 2002 Dec 6;324(4):691-702. PMID:12460571

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky

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