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Ferritin

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Crystal structure of Fe-soaked ferritin from the hyperthermophilic archael anaerobe Pyrococcus furiousus 2jd7

Drag the structure with the mouse to rotate

References

↑ Wang W, Knovich MA, Coffman LG, Torti FM, Torti SV. Serum ferritin: Past, present and future. Biochim Biophys Acta. 2010 Aug;1800(8):760-9. doi: 10.1016/j.bbagen.2010.03.011. , Epub 2010 Mar 19. PMID:20304033 doi:http://dx.doi.org/10.1016/j.bbagen.2010.03.011

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, David Canner, Eran Hodis, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Ferritin"

Category: Topic Page

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-[[Image:2jd7.jpg|left|350px]]
+<StructureSection load='' size='400' side='right' caption="Crystal structure of Fe-soaked ferritin from the hyperthermophilic archael anaerobe ''Pyrococcus furiousus'' [[2jd7]]" scene='Ferritin/Starting_ferritin_scene/1'>
-<applet load='Pdb2jd7.pdb' size='350' frame='true' align='right' scene="" caption='Crystal Structure of the Fe-Soaked Ferritin From the Hyperthermophilic Archael Anaerobe Pyrococcus Furiousus, [[2jd7]]' />
-'''3D Structure of Ferritin''' <br />
+== Function ==
-The image at the left is a Crystal Structure of the Ferritin from Pyrococcs Furiousus ([[2jd7]])
-==Ferritin==
+[[Ferritin]] (FR) is an iron storage and release protein.  It stores iron as microcrystals with phosphate and hydroxide ions. FR is composed of 24 subunits of heavy chain (FTH) and light chain (FTL).<ref>PMID:20304033</ref>  Amphibians have an additional middle subunit FR (FTM).<br />
+*  '''apo-ferritin''' (apo-FR) is a non-Fe-containing ferritin.<br />
+*   '''Bacterioferritin''' (BFR) structure is very similar to FR.  It contains a binuclear iron center and haem.  It stores iron as ferric oxide mineral in its hollow central cavity.<br />
+*  '''Thioferritin''' (TFR) is a ferritin-related protein with 2 cysteine residues adjacent to the dimetal binding site.<br />
+*  Another iron storing protein is the '''DNA-binding Protein of Starved cells''' (Dps) - a ferritin-like diiron carboxylate.<br />
+*  '''MrgA''' – another iron storage protein - belongs to the Dps family.
-Ferritin (FR) is an iron storage and release protein.  It stores iron as microcrystals with phosphate and hydroxide ions. FR is composed of 24 subunits of heavy chain (FTH) and light chain (FTL).   Bacterioferritin (BFR) structure is very similar to FR.  It contains a binuclear iron center and haem.  It stores iron as ferric oxide mineral in its hollow central cavity.  Thioferritin (TFR) is a ferritin-related protein with 2 Cysteine residues adjacent to the dimetal binding site.  Another iron storing protein is the DNA-binding Protein of Starved cells (Dps).  MrgA – another iron storage protein - belongs
+== Relevance ==
-to the Dps family.
-==3D Structures of Ferritin==
+Cavities formed by FR are used for the manufacture of nanoparticles.  FR is used as a marker for iron overload disorder.
-===Ferritin===
+== Disease ==
-[[2jd6]], [[2jd7]] – PfFR - Pyrococcus furiosus <br />
+FR deficiency can lead to anemia.
-[[2jd8]] – PfFR+Zn<br />
-[[3kxu]] – hFR (mutant) – human<br />
-[[3hx2]], [[3hx5]], [[3hx7]] - hFR<br />
-[[3a68]] – soFR from gene SferH4 – soybean<br />
-[[3a9q]] - soFR from gene SferH4 (mutant) <br />
-[[3egm]], [[3bvf]], [[3bvi]], [[3bvk]], [[3bvl]] – HpFR – Heliobacter pylori<br />
-[[3e6s]] - PnFR – Pseudo-nitzschia<br />
-[[1z4a]], [[1vlg]] – FR – Thermotoga maritime<br />
-[[1s3q]], [[1sq3]] – FR – Archaeoglubus fulgidus<br />
-[[1krq]] – FR – Campylobacter jejuni<br />
-[[1eum]]  - EcFR – Escherichia coli<br />
-[[1qgh]] – LiFR - Listeria innocua<br />
-[[1mfr]], [[1bg7]] – bFR - Bullfrog<br />
-===Ferritin light chain (FTL) ===
+==3D Structures of Ferritin==
+[[Ferritin 3D structures]]
-[[1lb3]], [[1h96]] – FTL – mouse<br />
-[[1rcc]], [[1rcd]], [[1rci]] – bFTL+tartrate+Mg<br />
-[[1rce]], [[1rcg]] - bFTL+tartrate+Mn<br />
-===Ferritin heavy chain (FTH) ===
-[[2z6m]], [[1r03]], [[2fha]] – hFTH<br />
-[[2z6o]] – FTH – Trichoplusia ni<br />
-===apo-ferritin (apo-FR) ===
-[[2x17]] – apo-PfFR+Ag <br />
-[[3h7g]] – apo-hoFR+Au – horse<br />
-[[1hrs]] - apo-hoFR+protoporphyrin<br />
-[[3bve]] – apo-HpFR<br />
-[[3e6r]] – apo-PnFR <br />
-[[2clu]], [[2cn6]] - apo-hFR (mutant)+Zn<br />
-===apo-ferritin light chain (apo-FTL) ===
-[[2zg7]], [[2z5p]], [[2z5q]], [[2z5r]], [[3fi6]] – apo-hoFTL+Pd<br />
-[[2zg8]], [[2zg9]] - apo-hoFTL (mutant)+Pd<br />
-[[3f33]], [[3f34]], [[3f35]], [[3f36]], [[3f37]], [[3f38]], [[3f39]] - apo-hoFTL+phenols<br />
-[[2v2i]], [[2v2j]] - apo-hoFTL+haemin<br />
-[[2gyd]] - apo-hoFTL+diaziflurane<br />
-[[1xz1]] - apo-hoFTL+halothane<br />
-[[1xz3]] - apo-hoFTL+isoflurane<br />
-[[1gwg]] - apo-hoFTL+I3<br />
-[[2w0o]] – apo-hoFTL<br />
-[[2v2l]], [[2v2m]], [[2v2n]], [[2v2o]], [[2v2p]], [[2v2r]], [[2v2s]] - apo-hoFTL (mutant)+haemin<br />
-[[2za6]], [[2g4h]], [[1aew]], [[1dat]], [[1ier]], [[1ies]], [[3f32]], [[2zur]] - apo-hoFTL<br />
-[[2ffx]], [[2fg4]], [[2fg8]] – apo-hFTL<br />
-===apo-ferritin heavy chain (apo-FTH) ===
-[[2za7]], [[2za8]], [[2cn7]], [[2chi]], [[2clu]] - apo-hoFTH (mutant) <br />
-[[2cei]], [[2cih]], [[2cn6]], [[2iu2]] - apo-hoFTH (mutant)+Zn<br />
-[[3erz]] – apo-hFR+Hg<br />
-[[3es3]] - apo-hFR+Au<br />
-===Bacterioferritin (BFR) ===
-[[3gvy]] – BFR – Rhodobacter sphaeroides<br />
-[[3fvb]] – BmBFR - Brucelia melitensis<br />
-[[2fkz]], [[2fl0]] – BFR – Azotobacrter vinelandii<br />
-[[1bfr]] – EcBFR <br />
-===Thioferritin (TFR) ===
-[[2vzb]] – TFR – Bacterioides fragilis
-===DNA-binding Protein of Starved cells (Dps) ===
+</StructureSection>
-[[3iq1]] – Dps – Vibrio cholerae<br />
-[[3ge4]] – BmDps <br />
-[[2iy4]] – Dps – Listeria monocytogenes<br />
-[[2bkc]], [[2bk6]], [[2bjy]] – LiDps (mutant) <br />
-[[2f7n]] – Dps – Deinococcus radiodurans<br />
-[[1tjo]], [[1tk6]], [[1tkp]], [[1moj]] – Dps – Halobacterium salinarum<br />
-[[1o9r]] – Dps – Agrobacterium tumefaciens<br />
-[[1dps]] – EcDps <br />
-===MrgA===
+== References ==
+<references/>
-[[2chp]] – MrgA – Bacillus subtilis<br />
+[[Category:Topic Page]]

Ferritin

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Contents

Function

Relevance

Disease

3D Structures of Ferritin

References

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