Fibrinogen

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[[Image:3hus2.jpg|left|300px|thumb|Crystal Structure of Fibrinogen with peptide ligand, [[3hus]]]]
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<StructureSection load='1n73' size='350' side='right' scene='41/410324/Cv/1' caption='Crystal structure of glycosylated fibrinogen fragment D. Subunit α (green and yellow), β (green and magenta), γ (pink and cyan) complex with the peptide ligand Gly-His-Arg-Pro-amide (red, wheat, blue, black) and Ca+2 ion (PDB code [[1n73]]) '>
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<applet load='3hus2.pdb' size='300' frame='true' align='right' scene="Fibrinogen/Fibrinogen_starting_scene/2" caption= 'Crystal structure of fibrinogen fragment D with the peptide ligand Gly-Pro-Arg-Pro-amide, [[3hus]]' />
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== Function ==
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'''Fibrinogen''' is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, [[thrombin]], exposing knobs A and B to form fibrin. <ref>PMID:16689770</ref> The fibrin forms clots to prevent excessive bleeding from wounds sustained. Clotting factors, like factor XIII, are often linked to fibrin. <ref>PMID:18673233</ref>
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'''3D Structure of Fibrinogen''' <br />
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==3D Printed Physical Model of Fibrinogen==
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The image at the left is a Crystal Structure of a Fibrinogen Fragment with the peptide ligand Gly-Pro-Arg-Pro-amide ([[3hus]])
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{{TOC limit|limit=2}}
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Shown below is a 3D printed physical model of Fibrinogen. The structure is shown as an alpha carbon backbone colored by chain, with the three chains of each copy of fibrinogen colored yellow, blue and purple.
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==Fibrinogen==
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[[Image:fibrinogen1_centerForBioMolecularModeling.jpg|550px]]
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Fibrinogen is composed of 3 non-identical chains alpha, beta, gamma (Fba, Fbb, Fbg) . Fibrinogen is cleaved by thrombin which exposes Knobs A & B to form fibrin - the blood clotting protein.
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====The MSOE Center for BioMolecular Modeling====
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[[Image:CbmUniversityLogo.jpg | left | 150px]]
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The [http://cbm.msoe.edu MSOE Center for BioMolecular Modeling] uses 3D printing technology to create physical models of protein and molecular structures, making the invisible molecular world more tangible and comprehensible. To view more protein structure models, visit our [http://cbm.msoe.edu/educationalmedia/modelgallery/ Model Gallery].
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== Structural insights ==
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Fibrinogen is composed of 2 copies each of 3 non-identical chains α, β, γ (<scene name='Fibrinogen/Fba/1'>Fba</scene>, <scene name='Fibrinogen/Fbb/1'>Fbb</scene>, <scene name='Fibrinogen/Fbg/1'>Fbg</scene>).
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</StructureSection>
==3D Structure of Fibrinogen==
==3D Structure of Fibrinogen==
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===Fibrinogen alpha+beta+gamma chains===
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Fibrinogen α+β+γ chains
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**[[3hus]], [[3h32]], [[3e1i]], [[3bvh]], [[2hlo]], [[2hod]], [[2hpc]], [[2oyh]], [[2oyi]], [[2h43]], [[2ffd]], [[1re3]], [[1rf1]], [[1n86]], [[1ltj]] – hFba+hFbb+hFbg+peptide ligand – human<br />
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**[[3ghg]], [[2q9i]], [[2z4e]] - hFba+hFbb+hFbg+knob A & B<br />
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**[[2xnx]], [[2xny]] - hFba+hFbb+hFbg + M1 protein<br />
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**[[2a45]] - hFba+hFbb+hFbg+thrombin+PPACK thrombin inhibitor<br />
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**[[1re4]], [[1rf0]], [[1n8e]], [[1lt9]] - hFba+hFbb+hFbg<br />
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**[[1jy3]], [[1deq]] – bFba+Fbb+Fbg – bovine<br />
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**[[1jy2]] - bFba+Fbb+Fbg proteolytic fragment<br />
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**[[1m1j]] - cFba+Fbb+Fbg+peptide ligand – chicken<br />
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**[[1ei3]] - cFba+Fbb+Fbg<br />
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**[[1n73]], [[1lwu]] - Fba+Fbb+Fbg+peptide ligand – Sea lamprey<br />
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[[3hus]], [[3h32]], [[3e1i]], [[3bvh]], [[2hlo]], [[2hod]], [[2hpc]], [[2oyh]], [[2oyi]], [[2h43]], [[2ffd]], [[1re3]], [[1rf1]], [[1n86]], [[1ltj]] – hFba+hFbb+hFbg+peptide ligand – human <br />
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*Fibrinogen α chain
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[[3ghg]], [[2q9i]], [[2z4e]] - hFba+hFbb+hFbg+knob A & B<br />
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[[2a45]] - hFba+hFbb+hFbg+thrombin+PPACK thrombin inhibitor<br />
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[[1re4]], [[1rf0]], [[1n8e]], [[1lt9]] - hFba+hFbb+hFbg<br />
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[[1jy3]], [[1deq]] – cFba+cFbb+cFbg - cow<br />
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[[1n73]], [[1lwu]] - Fba+Fbb+Fbg+peptide ligand – Sea lamprey<br />
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[[1m1j]] - heFba+heFbb+heFbg+peptide ligand – hen<br />
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[[1ei3]] - heFba+heFbb+heFbg<br />
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===Fibrinogen alpha chain===
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**[[1fzd]] – hFba EC domain<br />
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**[[1bbr]] – hFba+cε-thrombin<br />
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**[[2jor]] – bFba – NMR<br />
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**[[2baf]] – bFba<br />
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[[1fzd]] – hFba EC domain<br />
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*Fibrinogen β chain
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[[2jor]] – cFba – NMR<br />
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[[2baf]] – cFba<br />
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===Fibrinogen beta chain===
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**[[1fzf]], [[1fzg]] – hFb fragment double-D +peptide ligand<br />
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**[[1fze]], [[1fza]], [[1fzb]] – hFb fragment D<br />
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[[1fzf]], [[1fzg]] – hFb fragment double-D +peptide ligand<br />
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*Fibrinogen γ chain
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[[1fze]], [[1fza]], [[1fzb]] – hFb fragment D<br />
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===Fibrinogen gamma chain===
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**[[1fic]], [[1fid]] – hFbg<br />
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**[[3fib]] – hFbg C terminal<br />
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**[[2vr3]] – hFbg+SaClumping Factor A – ''Staphylococcus aureus''<br />
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**[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hFbg+Integrin alpha IIB+Integrin beta-3+ antibody <br />
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**[[2fib]], [[3fib]] - hFbg+peptide ligand<br />
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**[[1fib]] – hFbg+Ca<br />
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**[[2hwl]] – hFbg peptide+prothrombin<br />
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**[[2y7l]] – hFbg + agglutinin-like protein <br />
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**[[1dug]] – Fbg C-terminal/glutathione S-transferase – ''Schistosoma japonicum''<br />
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}}
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==References==
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<references />
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[[2vr3]] – hFbg+SaClumping Factor A – Staphylococcus aureus<br />
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[[Category:Topic Page]]
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[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hFbg+Integrin alpha IIB+Integrin beta-3+Monoclonal antibody heavy and light chains<br />
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[[2fib]], [[3fib]] - hFbg+peptide ligand<br />
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[[1fib]] – hFbg+Ca<br />
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[[1fic]], [[1fid]] - hFbg<br />
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Current revision

Crystal structure of glycosylated fibrinogen fragment D. Subunit α (green and yellow), β (green and magenta), γ (pink and cyan) complex with the peptide ligand Gly-His-Arg-Pro-amide (red, wheat, blue, black) and Ca+2 ion (PDB code 1n73)

Drag the structure with the mouse to rotate

3D Structure of Fibrinogen

Updated on 28-July-2020

References

  1. ↑ Betts L, Merenbloom BK, Lord ST. The structure of fibrinogen fragment D with the 'A' knob peptide GPRVVE. J Thromb Haemost. 2006 May;4(5):1139-41. PMID:16689770 doi:10.1111/j.1538-7836.2006.01902.x
  2. ↑ Muszbek L, Bagoly Z, Bereczky Z, Katona E. The involvement of blood coagulation factor XIII in fibrinolysis and thrombosis. Cardiovasc Hematol Agents Med Chem. 2008 Jul;6(3):190-205. PMID:18673233

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Michal Harel, David Canner, Mark Hoelzer, Alexander Berchansky, Angel Herraez

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