3llo

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{{Seed}}
 
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[[Image:3llo.png|left|200px]]
 
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==Crystal structure of the STAS domain of motor protein prestin (anion transporter SLC26A5)==
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The line below this paragraph, containing "STRUCTURE_3llo", creates the "Structure Box" on the page.
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<StructureSection load='3llo' size='340' side='right'caption='[[3llo]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3llo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LLO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.57&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene></td></tr>
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{{STRUCTURE_3llo| PDB=3llo | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3llo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3llo OCA], [https://pdbe.org/3llo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3llo RCSB], [https://www.ebi.ac.uk/pdbsum/3llo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3llo ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/S26A5_RAT S26A5_RAT] Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ll/3llo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3llo ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the STAS domain of motor protein prestin (anion transporter SLC26A5)===
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==See Also==
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*[[Prestin|Prestin]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 20471983 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20471983}}
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==About this Structure==
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3LLO is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LLO OCA].
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==Reference==
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<ref group="xtra">PMID:20471983</ref><references group="xtra"/>
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Aiello, R.]]
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[[Category: Aiello R]]
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[[Category: Battistutta, R.]]
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[[Category: Battistutta R]]
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[[Category: Bonetto, G.]]
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[[Category: Bonetto G]]
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[[Category: Pasqualetto, E.]]
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[[Category: Pasqualetto E]]
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[[Category: Cell shape]]
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[[Category: Glycoprotein]]
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[[Category: Membrane]]
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[[Category: Motor protein]]
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[[Category: Stas domain]]
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[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 28 11:49:47 2010''
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Current revision

Crystal structure of the STAS domain of motor protein prestin (anion transporter SLC26A5)

PDB ID 3llo

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OCA

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