3mex

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{{Seed}}
 
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[[Image:3mex.jpg|left|200px]]
 
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==Crystal structure of MexR in oxidized state==
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The line below this paragraph, containing "STRUCTURE_3mex", creates the "Structure Box" on the page.
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<StructureSection load='3mex' size='340' side='right'caption='[[3mex]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3mex]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MEX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MEX FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mex OCA], [https://pdbe.org/3mex PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mex RCSB], [https://www.ebi.ac.uk/pdbsum/3mex PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mex ProSAT]</span></td></tr>
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{{STRUCTURE_3mex| PDB=3mex | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MEXR_PSEAE MEXR_PSEAE] Repressor of the mexAB-oprM multidrug resistance operon. Also represses its own expression. Many variants lead to increased expression of the mexAB-oprM operon.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/me/3mex_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mex ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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MexR functions as the primary regulator of the mexAB-oprM multidrug efflux expression in Pseudomonas aeruginosa. It has been shown that MexR senses oxidative stress by interprotomer disulphide bond formation between redox-active cysteines. This oxidation induces MexR to dissociate from the promoter DNA, thus activating the transcriptional expression of efflux pump genes. In this study, we present the crystal structure of MexR in its oxidized form at a resolution of 2.1 A. This crystal structure reveals the mechanism by which oxidative signal allosterically derepresses the MexR-controlled transcription activation.
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===Crystal structure of MexR in oxidized state===
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Structural insight into the oxidation-sensing mechanism of the antibiotic resistance of regulator MexR.,Chen H, Yi C, Zhang J, Zhang W, Ge Z, Yang CG, He C EMBO Rep. 2010 Sep;11(9):685-90. Epub 2010 Jul 9. PMID:20616806<ref>PMID:20616806</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_20616806}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3mex" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20616806 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20616806}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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3MEX is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MEX OCA].
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[[Category: Pseudomonas aeruginosa PAO1]]
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[[Category: Chen H]]
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==Reference==
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[[Category: He C]]
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<ref group="xtra">PMID:20616806</ref><references group="xtra"/>
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[[Category: Yang C-G]]
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[[Category: Pseudomonas aeruginosa]]
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[[Category: Yi C]]
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[[Category: Chen, H.]]
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[[Category: Zhang J]]
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[[Category: He, C.]]
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[[Category: Zhang W]]
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[[Category: Yang, C G.]]
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[[Category: Yi, C.]]
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[[Category: Zhang, J.]]
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[[Category: Zhang, W.]]
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[[Category: Antibiotics resistance regulation]]
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[[Category: Dna-binding]]
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[[Category: Oxidative stress]]
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[[Category: Thiol modification]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 28 12:38:45 2010''
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Current revision

Crystal structure of MexR in oxidized state

PDB ID 3mex

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