2l14
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2l14 is ON HOLD Authors: Lee, C., Martinez-Yamout, M.A., Dyson, H.J., Wright, P.E. Description: Structure of CBP nuclear coactivator binding domain...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of CBP nuclear coactivator binding domain in complex with p53 TAD== | |
| + | <StructureSection load='2l14' size='340' side='right'caption='[[2l14]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2l14]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L14 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l14 OCA], [https://pdbe.org/2l14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l14 RCSB], [https://www.ebi.ac.uk/pdbsum/2l14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l14 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CBP_MOUSE CBP_MOUSE] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 (By similarity).<ref>PMID:10207073</ref> <ref>PMID:11701890</ref> <ref>PMID:15220471</ref> <ref>PMID:16287980</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[CREB-binding protein 3D structures|CREB-binding protein 3D structures]] | |
| - | + | *[[P53 3D structures|P53 3D structures]] | |
| - | + | == References == | |
| - | + | <references/> | |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Dyson HJ]] | ||
| + | [[Category: Lee C]] | ||
| + | [[Category: Martinez-Yamout MA]] | ||
| + | [[Category: Wright PE]] | ||
Current revision
Structure of CBP nuclear coactivator binding domain in complex with p53 TAD
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