2xaa

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{{Seed}}
 
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[[Image:2xaa.jpg|left|200px]]
 
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==Alcohol dehydrogenase ADH-'A' from Rhodococcus ruber DSM 44541 at pH 8.5 in complex with NAD and butane-1,4-diol==
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The line below this paragraph, containing "STRUCTURE_2xaa", creates the "Structure Box" on the page.
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<StructureSection load='2xaa' size='340' side='right'caption='[[2xaa]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2xaa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_ruber Rhodococcus ruber]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XAA FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2xaa| PDB=2xaa | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xaa OCA], [https://pdbe.org/2xaa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xaa RCSB], [https://www.ebi.ac.uk/pdbsum/2xaa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xaa ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8KLT9_9NOCA Q8KLT9_9NOCA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xa/2xaa_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xaa ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of the alcohol dehydrogenase ADH-'A' from Rhodococcus ruber reveals possible reasons for its remarkable tolerance to organic co-solvents and suggests new directions for structure-informed mutagenesis to produce enzymes of altered substrate specificity or improved selectivity.
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===ALCOHOL DEHYDROGENASE ADH-'A' FROM RHODOCOCCUS RUBER DSM 44541 AT PH 8.5 IN COMPLEX WITH NAD AND BUTANE-1,4-DIOL===
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Structural insights into substrate specificity and solvent tolerance in alcohol dehydrogenase ADH-'A' from Rhodococcus ruber DSM 44541.,Karabec M, Lyskowski A, Tauber KC, Steinkellner G, Kroutil W, Grogan G, Gruber K Chem Commun (Camb). 2010 Aug 2. PMID:20676439<ref>PMID:20676439</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2xaa" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_20676439}}, adds the Publication Abstract to the page
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*[[Alcohol dehydrogenase 3D structures|Alcohol dehydrogenase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 20676439 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20676439}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2XAA is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Rhodococcus_ruber Rhodococcus ruber]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAA OCA].
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==Reference==
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<ref group="xtra">PMID:20676439</ref><references group="xtra"/>
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[[Category: Alcohol dehydrogenase]]
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[[Category: Rhodococcus ruber]]
[[Category: Rhodococcus ruber]]
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[[Category: Grogan, G.]]
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[[Category: Grogan G]]
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[[Category: Gruber, K.]]
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[[Category: Gruber K]]
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[[Category: Kroutil, W.]]
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[[Category: Kroutil W]]
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[[Category: Carbonyl reductase]]
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[[Category: Ketoreductase]]
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[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 11 23:48:29 2010''
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Current revision

Alcohol dehydrogenase ADH-'A' from Rhodococcus ruber DSM 44541 at pH 8.5 in complex with NAD and butane-1,4-diol

PDB ID 2xaa

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