3n3e

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{{Seed}}
 
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[[Image:3n3e.jpg|left|200px]]
 
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==Zebrafish AlphaA crystallin==
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The line below this paragraph, containing "STRUCTURE_3n3e", creates the "Structure Box" on the page.
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<StructureSection load='3n3e' size='340' side='right'caption='[[3n3e]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3n3e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N3E FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n3e OCA], [https://pdbe.org/3n3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n3e RCSB], [https://www.ebi.ac.uk/pdbsum/3n3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n3e ProSAT]</span></td></tr>
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{{STRUCTURE_3n3e| PDB=3n3e | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8UUZ6_DANRE Q8UUZ6_DANRE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n3/3n3e_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n3e ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In previous work on truncated alpha crystallins (Laganowsky et al., Protein Sci 2010; 19:1031-1043), we determined crystal structures of the alpha crystallin core, a seven beta-stranded immunoglobulin-like domain, with its conserved C-terminal extension. These extensions swap into neighboring cores forming oligomeric assemblies. The extension is palindromic in sequence, binding in either of two directions. Here, we report the crystal structure of a truncated alphaA crystallin (AAC) from zebrafish (Danio rerio) revealing C-terminal extensions in a non three-dimensional (3D) domain swapped, "closed" state. The extension is quasi-palindromic, bound within its own zebrafish core domain, lying in the opposite direction to that of bovine AAC, which is bound within an adjacent core domain (Laganowsky et al., Protein Sci 2010; 19:1031-1043). Our findings establish that the C-terminal extension of alpha crystallin proteins can be either 3D domain swapped or non-3D domain swapped. This duality provides another molecular mechanism for alpha crystallin proteins to maintain the polydispersity that is crucial for eye lens transparency.
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===Zebrafish AlphaA crystallin===
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Non-3D domain swapped crystal structure of truncated zebrafish alphaA crystallin.,Laganowsky A, Eisenberg D Protein Sci. 2010 Oct;19(10):1978-84. PMID:20669149<ref>PMID:20669149</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3n3e" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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3N3E is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N3E OCA].
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*[[Crystallin 3D structures|Crystallin 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Danio rerio]]
[[Category: Danio rerio]]
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[[Category: Eisenberg, D.]]
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[[Category: Large Structures]]
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[[Category: Laganowsky, A.]]
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[[Category: Eisenberg D]]
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[[Category: Chaperone]]
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[[Category: Laganowsky A]]
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[[Category: Eye lens transparency]]
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[[Category: Protein chaperone]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 11 23:58:14 2010''
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Current revision

Zebrafish AlphaA crystallin

PDB ID 3n3e

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