2jc6

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[[Image:2jc6.gif|left|200px]]<br /><applet load="2jc6" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2jc6, resolution 2.30&Aring;" />
 
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'''CRYSTAL STRUCTURE OF HUMAN CALMODULIN-DEPENDENT PROTEIN KINASE 1D'''<br />
 
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==About this Structure==
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==Crystal structure of human calmodulin-dependent protein kinase 1D==
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2JC6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with QPP as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] Known structural/functional Site: <scene name='pdbsite=AC1:Qpp Binding Site For Chain C'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JC6 OCA].
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<StructureSection load='2jc6' size='340' side='right'caption='[[2jc6]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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[[Category: Calcium/calmodulin-dependent protein kinase]]
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== Structural highlights ==
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[[Category: Homo sapiens]]
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<table><tr><td colspan='2'>[[2jc6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JC6 FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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[[Category: Arrowsmith, C.H.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QPP:N-(5-METHYL-1H-PYRAZOL-3-YL)-2-PHENYLQUINAZOLIN-4-AMINE'>QPP</scene></td></tr>
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[[Category: Berridge, G.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jc6 OCA], [https://pdbe.org/2jc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jc6 RCSB], [https://www.ebi.ac.uk/pdbsum/2jc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jc6 ProSAT]</span></td></tr>
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[[Category: Bhatia, C.]]
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</table>
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[[Category: Bunkoczi, G.]]
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== Function ==
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[[Category: Colebrook, S.]]
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[https://www.uniprot.org/uniprot/KCC1D_HUMAN KCC1D_HUMAN] Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.<ref>PMID:11050006</ref> <ref>PMID:15840691</ref> <ref>PMID:16324104</ref> <ref>PMID:17056143</ref>
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[[Category: Debreczeni, J.E.]]
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== Evolutionary Conservation ==
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[[Category: Delft, F.Von.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Edwards, A.]]
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Check<jmol>
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[[Category: Fedorov, O.]]
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<jmolCheckbox>
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[[Category: Gileadi, O.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jc/2jc6_consurf.spt"</scriptWhenChecked>
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[[Category: Knapp, S.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Niesen, F.H.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Pike, A.C.W.]]
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</jmolCheckbox>
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[[Category: Rellos, P.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jc6 ConSurf].
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[[Category: Salah, E.]]
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<div style="clear:both"></div>
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[[Category: Shrestha, L.]]
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[[Category: Smee, C.]]
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[[Category: Sundstrom, M.]]
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[[Category: Ugochukwu, E.]]
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[[Category: Weigelt, J.]]
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[[Category: QPP]]
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[[Category: allosteric enzyme]]
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[[Category: alternative splicing]]
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[[Category: atp-binding]]
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[[Category: calcium]]
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[[Category: calmodulin-binding]]
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[[Category: kinase]]
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[[Category: nuclear protein]]
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[[Category: nucleotide-binding]]
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[[Category: phosphorylation]]
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[[Category: serine/threonine-protein kinase]]
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[[Category: transferase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 19:59:51 2007''
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==See Also==
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*[[Calcium/calmodulin dependent protein kinase 3D structures|Calcium/calmodulin dependent protein kinase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Berridge G]]
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[[Category: Bhatia C]]
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[[Category: Bunkoczi G]]
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[[Category: Colebrook S]]
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[[Category: Debreczeni JE]]
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[[Category: Edwards A]]
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[[Category: Fedorov O]]
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[[Category: Gileadi O]]
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[[Category: Knapp S]]
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[[Category: Niesen FH]]
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[[Category: Pike ACW]]
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[[Category: Rellos P]]
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[[Category: Salah E]]
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[[Category: Shrestha L]]
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[[Category: Smee C]]
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[[Category: Sundstrom M]]
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[[Category: Ugochukwu E]]
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[[Category: Weigelt J]]
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[[Category: Von Delft F]]

Current revision

Crystal structure of human calmodulin-dependent protein kinase 1D

PDB ID 2jc6

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