3alx
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3alx is ON HOLD Authors: Hashiguchi, T, Ose, T, Maenaka, K, Yanagi, Y Description: Crystal structure of the measles virus hemagglutinin bound to it...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the measles virus hemagglutinin bound to its cellular receptor SLAM (MV-H(L482R)-SLAM(N102H/R108Y) fusion)== | |
| + | <StructureSection load='3alx' size='340' side='right'caption='[[3alx]], [[Resolution|resolution]] 3.15Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3alx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Measles_morbillivirus Measles morbillivirus], [https://en.wikipedia.org/wiki/Saguinus_oedipus Saguinus oedipus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ALX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ALX FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.15Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3alx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3alx OCA], [https://pdbe.org/3alx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3alx RCSB], [https://www.ebi.ac.uk/pdbsum/3alx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3alx ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/E2RZS2_9MONO E2RZS2_9MONO] [https://www.uniprot.org/uniprot/Q9GJT3_SAGOE Q9GJT3_SAGOE] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Measles virus, a major cause of childhood morbidity and mortality worldwide, predominantly infects immune cells using signaling lymphocyte activation molecule (SLAM) as a cellular receptor. Here we present crystal structures of measles virus hemagglutinin (MV-H), the receptor-binding glycoprotein, in complex with SLAM. The MV-H head domain binds to a beta-sheet of the membrane-distal ectodomain of SLAM using the side of its beta-propeller fold. This is distinct from attachment proteins of other paramyxoviruses that bind receptors using the top of their beta-propeller. The structure provides templates for antiviral drug design, an explanation for the effectiveness of the measles virus vaccine, and a model of the homophilic SLAM-SLAM interaction involved in immune modulations. Notably, the crystal structures obtained show two forms of the MV-H-SLAM tetrameric assembly (dimer of dimers), which may have implications for the mechanism of fusion triggering. | ||
| - | + | Structure of the measles virus hemagglutinin bound to its cellular receptor SLAM.,Hashiguchi T, Ose T, Kubota M, Maita N, Kamishikiryo J, Maenaka K, Yanagi Y Nat Struct Mol Biol. 2011 Feb;18(2):135-41. Epub 2011 Jan 9. PMID:21217702<ref>PMID:21217702</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 3alx" style="background-color:#fffaf0;"></div> | ||
| - | + | ==See Also== | |
| + | *[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Measles morbillivirus]] | ||
| + | [[Category: Saguinus oedipus]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Hashiguchi T]] | ||
| + | [[Category: Kamishikiryo J]] | ||
| + | [[Category: Kubota M]] | ||
| + | [[Category: Maenaka K]] | ||
| + | [[Category: Maita N]] | ||
| + | [[Category: Ose T]] | ||
| + | [[Category: Yanagi Y]] | ||
Current revision
Crystal structure of the measles virus hemagglutinin bound to its cellular receptor SLAM (MV-H(L482R)-SLAM(N102H/R108Y) fusion)
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