2kor

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{{Seed}}
 
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[[Image:2kor.jpg|left|200px]]
 
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==NMR solution structures of 2-octenoyl-ACP from Streptomyces coelicolor Fatty Acid Synthase==
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The line below this paragraph, containing "STRUCTURE_2kor", creates the "Structure Box" on the page.
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<StructureSection load='2kor' size='340' side='right'caption='[[2kor]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2kor]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"actinomyces_coelicolor"_(muller_1908)_lieske_1921 "actinomyces coelicolor" (muller 1908) lieske 1921]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KOR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SOO:S-[2-[3-[[(2S)-2-HYDROXY-3,3-DIMETHYL-4-PHOSPHONOOXY-BUTANOYL]AMINO]PROPANOYLAMINO]ETHYL]+(E)-OCT-2-ENETHIOATE'>SOO</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2koo|2koo]], [[2kop|2kop]], [[2koq|2koq]], [[2kos|2kos]]</div></td></tr>
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{{STRUCTURE_2kor| PDB=2kor | SCENE= }}
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">acpP, SCO2389, SC4A7.17 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1902 "Actinomyces coelicolor" (Muller 1908) Lieske 1921])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kor OCA], [https://pdbe.org/2kor PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kor RCSB], [https://www.ebi.ac.uk/pdbsum/2kor PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kor ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/P72393_STRCH P72393_STRCH]] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[HAMAP-Rule:MF_01217][RuleBase:RU003545]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/2kor_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kor ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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It remains unclear whether in a bacterial fatty acid synthase (FAS) acyl chain transfer is a programmed or diffusion controlled and random action. Acyl carrier protein (ACP), which delivers all intermediates and interacts with all synthase enzymes, is the key player in this process. High-resolution structures of intermediates covalently bound to an ACP representing each step in fatty acid biosynthesis have been solved by solution NMR. These include hexanoyl-, 3-oxooctanyl-, 3R-hydroxyoctanoyl-, 2-octenoyl-, and octanoyl-ACP from Streptomyces coelicolor FAS. The high-resolution structures reveal that the ACP adopts a unique conformation for each intermediate driven by changes in the internal fatty acid binding pocket. The binding of each intermediate shows conserved structural features that may ensure effective molecular recognition over subsequent rounds of fatty acid biosynthesis.
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===NMR solution structures of 2-octenoyl-ACP from Streptomyces coelicolor Fatty Acid Synthase===
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Recognition of intermediate functionality by acyl carrier protein over a complete cycle of fatty acid biosynthesis.,Ploskon E, Arthur CJ, Kanari AL, Wattana-amorn P, Williams C, Crosby J, Simpson TJ, Willis CL, Crump MP Chem Biol. 2010 Jul 30;17(7):776-85. PMID:20659690<ref>PMID:20659690</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2kor" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_20659690}}, adds the Publication Abstract to the page
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*[[Acyl carrier protein 3D structures|Acyl carrier protein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 20659690 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20659690}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2KOR is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOR OCA].
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[[Category: Arthur, C J]]
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[[Category: Crump, M P]]
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==Reference==
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[[Category: Ploskon, E]]
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<ref group="xtra">PMID:20659690</ref><references group="xtra"/>
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[[Category: Streptomyces coelicolor]]
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[[Category: Arthur, C J.]]
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[[Category: Crump, M P.]]
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[[Category: Ploskon, E.]]
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[[Category: Acyl carrier protein]]
[[Category: Acyl carrier protein]]
[[Category: Fatty acid biosynthesis]]
[[Category: Fatty acid biosynthesis]]
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[[Category: Phosphopantetheine]]
[[Category: Phosphopantetheine]]
[[Category: Transport protein]]
[[Category: Transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 18 11:34:18 2010''
 

Current revision

NMR solution structures of 2-octenoyl-ACP from Streptomyces coelicolor Fatty Acid Synthase

PDB ID 2kor

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