3ly6

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{{Seed}}
 
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[[Image:3ly6.jpg|left|200px]]
 
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==Crystal structure of human transglutaminase 2 complex with adenosine 5' Triphosphate==
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The line below this paragraph, containing "STRUCTURE_3ly6", creates the "Structure Box" on the page.
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<StructureSection load='3ly6' size='340' side='right'caption='[[3ly6]], [[Resolution|resolution]] 3.14&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ly6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LY6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.14&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
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{{STRUCTURE_3ly6| PDB=3ly6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ly6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ly6 OCA], [https://pdbe.org/3ly6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ly6 RCSB], [https://www.ebi.ac.uk/pdbsum/3ly6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ly6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TGM2_HUMAN TGM2_HUMAN] Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ly/3ly6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ly6 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Transglutaminase 2 (TG2) is a calcium-dependent multifunctional protein associated with various human diseases. We determined the crystal structure of human TG2 in complex with adenosine triphosphate (ATP). The ATP molecule binds to the previously identified guanosine diphosphate (GDP) binding pocket but has different hydrogen bonds and ion interaction with protein. The four residues Arg476, Arg478, Val479 and Tyr583, all of which are involved in both ATP and GDP binding by hydrogen bonds, might play important roles in the stabilization of TG2 by ATP or GDP. However, Ser482 and Arg580, which are involved in GDP binding, do not form hydrogen bond with ATP. Additionally, we newly discovered an intramolecular disulfide bond between Cys230 and Cys370, which formation might regulate the enzymatic activity of TG2.
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===Crystal structure of human transglutaminase 2 complex with adenosine 5' Triphosphate===
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Crystal structure of human transglutaminase 2 in complex with adenosine triphosphate.,Han BG, Cho JW, Cho YD, Jeong KC, Kim SY, Lee BI Int J Biol Macromol. 2010 Aug 1;47(2):190-5. Epub 2010 May 5. PMID:20450932<ref>PMID:20450932</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_20450932}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3ly6" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20450932 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20450932}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3LY6 is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LY6 OCA].
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==Reference==
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<ref group="xtra">PMID:20450932</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein-glutamine gamma-glutamyltransferase]]
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[[Category: Large Structures]]
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[[Category: Han, B G.]]
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[[Category: Han BG]]
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[[Category: Lee, B I.]]
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[[Category: Lee BI]]
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[[Category: Acyltransferase]]
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[[Category: Diabetes mellitus]]
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[[Category: Disease mutation]]
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[[Category: Metal-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Transferase]]
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[[Category: Transglutaminase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 18 11:44:18 2010''
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Current revision

Crystal structure of human transglutaminase 2 complex with adenosine 5' Triphosphate

PDB ID 3ly6

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