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2ell

From Proteopedia

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{{Seed}}
 
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[[Image:2ell.png|left|200px]]
 
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<!--
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==Solution structure of the Leucine Rich Repeat of human Acidic leucine-rich nuclear phosphoprotein 32 family member B==
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The line below this paragraph, containing "STRUCTURE_2ell", creates the "Structure Box" on the page.
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<StructureSection load='2ell' size='340' side='right'caption='[[2ell]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ell]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ELL FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ell FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ell OCA], [https://pdbe.org/2ell PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ell RCSB], [https://www.ebi.ac.uk/pdbsum/2ell PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ell ProSAT], [https://www.topsan.org/Proteins/RSGI/2ell TOPSAN]</span></td></tr>
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{{STRUCTURE_2ell| PDB=2ell | SCENE= }}
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</table>
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== Function ==
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===Solution structure of the Leucine Rich Repeat of human Acidic leucine-rich nuclear phosphoprotein 32 family member B===
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[https://www.uniprot.org/uniprot/AN32B_HUMAN AN32B_HUMAN] Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.<ref>PMID:20538007</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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<!--
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_20538007}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 20538007 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/el/2ell_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_20538007}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ell ConSurf].
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2ELL is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELL OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:20538007</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Harada, T.]]
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[[Category: Large Structures]]
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[[Category: Kigawa, T.]]
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[[Category: Harada T]]
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[[Category: Koshiba, S.]]
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[[Category: Kigawa T]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Koshiba S]]
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[[Category: Tanaka, A.]]
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[[Category: Tanaka A]]
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[[Category: Tochio, N.]]
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[[Category: Tochio N]]
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[[Category: Umehara, T.]]
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[[Category: Umehara T]]
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[[Category: Watanabe, S.]]
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[[Category: Watanabe S]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: Acidic protein rich in leucine]]
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[[Category: Gene regulation]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Phapi2 protein]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Silver-stainable protein ssp29]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 25 08:18:50 2010''
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Current revision

Solution structure of the Leucine Rich Repeat of human Acidic leucine-rich nuclear phosphoprotein 32 family member B

PDB ID 2ell

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OCA

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