3odk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:34, 21 February 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 3odk is ON HOLD until Paper Publication
+
==Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution==
 +
<StructureSection load='3odk' size='340' side='right'caption='[[3odk]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[3odk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ODK FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ODK:3-PYRIDIN-2-YL-1H-PYRAZOLE-5-CARBOXYLIC+ACID'>ODK</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3odk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3odk OCA], [https://pdbe.org/3odk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3odk RCSB], [https://www.ebi.ac.uk/pdbsum/3odk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3odk ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>
-
Authors: Potter, A., Oldfield, V., Nunns, C., Fromont, C., Ray, S., Northfield, C.J., Bryant, C.J., Scrace, S.F., Robinson, D., Matossova, N., Baker, L., Dokurno, P., Surgenor, A.E., Davis, B.E., Richardson, C.M., Murray, J.B., Moore, J.D.
+
==See Also==
-
 
+
*[[Peptidyl-prolyl cis-trans isomerase 3D structures|Peptidyl-prolyl cis-trans isomerase 3D structures]]
-
Description: Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution
+
== References ==
-
 
+
<references/>
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 25 08:38:25 2010''
+
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Baker L]]
 +
[[Category: Bryant CJ]]
 +
[[Category: Davis BE]]
 +
[[Category: Dokurno P]]
 +
[[Category: Fromont C]]
 +
[[Category: Matossova N]]
 +
[[Category: Moore JD]]
 +
[[Category: Murray JB]]
 +
[[Category: Northfield CJ]]
 +
[[Category: Nunns C]]
 +
[[Category: Oldfield V]]
 +
[[Category: Potter A]]
 +
[[Category: Ray S]]
 +
[[Category: Richardson CM]]
 +
[[Category: Robinson D]]
 +
[[Category: Scrace SF]]
 +
[[Category: Surgenor AE]]

Current revision

Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution

PDB ID 3odk

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3odk"
Personal tools