1wuw

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{{Seed}}
 
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[[Image:1wuw.png|left|200px]]
 
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==Crystal Structure of beta hordothionin==
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The line below this paragraph, containing "STRUCTURE_1wuw", creates the "Structure Box" on the page.
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<StructureSection load='1wuw' size='340' side='right'caption='[[1wuw]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wuw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hordeum_vulgare Hordeum vulgare]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WUW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SER:SERINE'>SER</scene>, <scene name='pdbligand=TSU:PARA-TOLUENE+SULFONATE'>TSU</scene></td></tr>
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{{STRUCTURE_1wuw| PDB=1wuw | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wuw OCA], [https://pdbe.org/1wuw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wuw RCSB], [https://www.ebi.ac.uk/pdbsum/1wuw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wuw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/THNB_HORVU THNB_HORVU] Thionins are small plant proteins which are toxic to animal cells. They seem to exert their toxic effect at the level of the cell membrane. Their precise function is not known.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wu/1wuw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wuw ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Crystal structure of ubiquitous toxin from barley alpha-hordothionin (alpha-HT) has been determined at 1.9A resolution by X-ray crystallography. The primary sequence as well as the NMR solution structure of alpha-HT firmly established that alpha-HT belongs to a family of membrane active plant toxins-thionins. Since alpha-HT crystallized in a space group (P4(1)2(1)2) that is different from the space group (I422) of previously determined alpha(1)- and beta-purothionins, and visocotoxin A3, therefore, it provided independent information on protein-protein interactions that may be relevant to the toxin mechanism. The structure of alpha-HT not only confirms overall architectural features (crambin fold) but also provides an additional confirmation of the role for crucial solute molecules, that were postulated to be directly involved in the mechanism of toxicity for thionins.
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===Crystal Structure of beta hordothionin===
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Crystal structure of alpha-hordothionin at 1.9 Angstrom resolution.,Johnson KA, Kim E, Teeter MM, Suh SW, Stec B FEBS Lett. 2005 Apr 25;579(11):2301-6. PMID:15848162<ref>PMID:15848162</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15848162}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1wuw" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15848162 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15848162}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1WUW is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Hordeum_vulgare Hordeum vulgare]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUW OCA].
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==Reference==
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<ref group="xtra">PMID:15848162</ref><references group="xtra"/>
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[[Category: Hordeum vulgare]]
[[Category: Hordeum vulgare]]
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[[Category: Johnson, K A.]]
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[[Category: Large Structures]]
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[[Category: Kim, E.]]
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[[Category: Johnson KA]]
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[[Category: Stec, B.]]
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[[Category: Kim E]]
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[[Category: Suh, S W.]]
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[[Category: Stec B]]
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[[Category: Teeter, M M.]]
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[[Category: Suh SW]]
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[[Category: Crambin fold]]
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[[Category: Teeter MM]]
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[[Category: Dimer]]
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[[Category: Plant protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 1 09:13:11 2010''
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Current revision

Crystal Structure of beta hordothionin

PDB ID 1wuw

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