3m1c

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:09, 6 November 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3m1c.png|left|200px]]
 
-
<!--
+
==Crystal structure of the conserved herpesvirus fusion regulator complex gH-gL==
-
The line below this paragraph, containing "STRUCTURE_3m1c", creates the "Structure Box" on the page.
+
<StructureSection load='3m1c' size='340' side='right'caption='[[3m1c]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3m1c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_herpesvirus_2_strain_HG52 Human herpesvirus 2 strain HG52]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M1C FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=XYL:D-XYLITOL'>XYL</scene></td></tr>
-
{{STRUCTURE_3m1c| PDB=3m1c | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m1c OCA], [https://pdbe.org/3m1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m1c RCSB], [https://www.ebi.ac.uk/pdbsum/3m1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m1c ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/GH_HHV2H GH_HHV2H] The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding of gD to one of its receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis (By similarity).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m1/3m1c_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3m1c ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Herpesviruses, which cause many incurable diseases, infect cells by fusing viral and cellular membranes. Whereas most other enveloped viruses use a single viral catalyst called a fusogen, herpesviruses, inexplicably, require two conserved fusion-machinery components, gB and the heterodimer gH-gL, plus other nonconserved components. gB is a class III viral fusogen, but unlike other members of its class, it does not function alone. We determined the crystal structure of the gH ectodomain bound to gL from herpes simplex virus 2. gH-gL is an unusually tight complex with a unique architecture that, unexpectedly, does not resemble any known viral fusogen. Instead, we propose that gH-gL activates gB for fusion, possibly through direct binding. Formation of a gB-gH-gL complex is critical for fusion and is inhibited by a neutralizing antibody, making the gB-gH-gL interface a promising antiviral target.
-
===Crystal structure of the conserved herpesvirus fusion regulator complex gH-gL===
+
Crystal structure of the conserved herpesvirus fusion regulator complex gH-gL.,Chowdary TK, Cairns TM, Atanasiu D, Cohen GH, Eisenberg RJ, Heldwein EE Nat Struct Mol Biol. 2010 Jul;17(7):882-8. Epub 2010 Jul 4. PMID:20601960<ref>PMID:20601960</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_20601960}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 3m1c" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 20601960 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_20601960}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Human herpesvirus 2 strain HG52]]
-
3M1C is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Human_herpesvirus_2 Human herpesvirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M1C OCA].
+
[[Category: Large Structures]]
-
 
+
[[Category: Chowdary TK]]
-
==Reference==
+
[[Category: Heldwein EE]]
-
<ref group="xtra">PMID:20601960</ref><references group="xtra"/>
+
-
[[Category: Human herpesvirus 2]]
+
-
[[Category: Chowdary, T K.]]
+
-
[[Category: Heldwein, E E.]]
+
-
[[Category: Disulfide bond]]
+
-
[[Category: Envelope protein]]
+
-
[[Category: Gh/gl]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: Glycoprotein h]]
+
-
[[Category: Glycoprotein l]]
+
-
[[Category: Herpes simplex virus]]
+
-
[[Category: Host cell membrane]]
+
-
[[Category: Host endosome]]
+
-
[[Category: Host membrane]]
+
-
[[Category: Membrane]]
+
-
[[Category: Transmembrane]]
+
-
[[Category: Viral protein]]
+
-
[[Category: Virion]]
+
-
[[Category: Virus reference strain]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 1 09:17:47 2010''
+

Current revision

Crystal structure of the conserved herpesvirus fusion regulator complex gH-gL

PDB ID 3m1c

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3m1c"
Personal tools