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2wq9

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{{Seed}}
 
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[[Image:2wq9.jpg|left|200px]]
 
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==Crystal Structure of RBP4 bound to Oleic Acid==
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The line below this paragraph, containing "STRUCTURE_2wq9", creates the "Structure Box" on the page.
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<StructureSection load='2wq9' size='340' side='right'caption='[[2wq9]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2wq9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WQ9 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>
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{{STRUCTURE_2wq9| PDB=2wq9 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wq9 OCA], [https://pdbe.org/2wq9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wq9 RCSB], [https://www.ebi.ac.uk/pdbsum/2wq9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wq9 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN] Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:[https://omim.org/entry/180250 180250]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium.
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== Function ==
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[https://www.uniprot.org/uniprot/RET4_HUMAN RET4_HUMAN] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wq/2wq9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wq9 ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF RBP4 BOUND TO OLEIC ACID===
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==See Also==
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*[[Multiple sclerosis|Multiple sclerosis]]
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*[[Retinol-binding protein 3D structures|Retinol-binding protein 3D structures]]
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==About this Structure==
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__TOC__
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2WQ9 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQ9 OCA].
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Buckley, D.]]
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[[Category: Large Structures]]
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[[Category: Mercer, D.]]
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[[Category: Buckley D]]
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[[Category: Nanao, M.]]
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[[Category: Mercer D]]
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[[Category: Nguyen, L.]]
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[[Category: Nanao M]]
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[[Category: Stout, T J.]]
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[[Category: Nguyen L]]
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[[Category: Disease mutation]]
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[[Category: Stout TJ]]
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[[Category: Retinol-binding]]
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[[Category: Sensory transduction]]
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[[Category: Signaling protein]]
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[[Category: Vision]]
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[[Category: Vitamin some]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 1 09:45:12 2010''
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Current revision

Crystal Structure of RBP4 bound to Oleic Acid

PDB ID 2wq9

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