3my2

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{{Seed}}
 
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[[Image:3my2.jpg|left|200px]]
 
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==Crystal structure of LptC==
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The line below this paragraph, containing "STRUCTURE_3my2", creates the "Structure Box" on the page.
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<StructureSection load='3my2' size='340' side='right'caption='[[3my2]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3my2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_str._K-12_substr._MG1655 Escherichia coli str. K-12 substr. MG1655]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MY2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MY2 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3my2| PDB=3my2 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3my2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3my2 OCA], [https://pdbe.org/3my2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3my2 RCSB], [https://www.ebi.ac.uk/pdbsum/3my2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3my2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LPTC_ECOLI LPTC_ECOLI] Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. It facilitates the transfer of LPS from the inner membrane to a periplasmic chaperone, LptA.<ref>PMID:16765569</ref> <ref>PMID:18424520</ref> <ref>PMID:20720015</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/my/3my2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3my2 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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LptC is a conserved bitopic inner membrane protein from Escherichia coli involved in the export of lipopolysaccharide from its site of synthesis in the cytoplasmic membrane to the outer membrane. LptC forms a complex with the ATP-binding cassette transporter, LptBFG, which is thought to facilitate the extraction of lipopolysaccharide from the inner membrane and release it into a translocation pathway that includes the putative periplasmic chaperone LptA. Cysteine-modification experiments established that the catalytic domain of LptC is oriented towards the periplasm. The structure of the periplasmic domain is described at a resolution of 2.2-angstroms from X-ray crystallographic data. The periplasmic domain of LptC consists of a twisted-boat structure with two beta-sheets in apposition to each other. The beta-sheets contain seven and eight anti-parallel beta-strands, respectively. This structure bears a high degree of resemblance to the crystal structure of LptA. Like LptA, LptC binds lipopolysaccharide in vitro. In vitro, LptA can displace lipopolysaccharide from LptC (but not vice versa), consistent with their locations and their proposed placement in a unidirectional export pathway.
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===Crystal structure of LptC===
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Structure and functional analysis of LptC, a conserved membrane protein involved in the lipopolysaccharide export pathway in Escherichia coll.,Tran AX, Dong C, Whitfield C J Biol Chem. 2010 Aug 18. PMID:20720015<ref>PMID:20720015</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_20720015}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3my2" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20720015 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20720015}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Escherichia coli str. K-12 substr. MG1655]]
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3MY2 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MY2 OCA].
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[[Category: Large Structures]]
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[[Category: Dong C]]
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==Reference==
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[[Category: Tran AX]]
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<ref group="xtra">PMID:20720015</ref><references group="xtra"/>
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[[Category: Whitfield C]]
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[[Category: Escherichia coli]]
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[[Category: Dong, C.]]
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[[Category: SSPF, Scottish Structural Proteomics Facility.]]
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[[Category: Tran, A X.]]
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[[Category: Whitfield, C.]]
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[[Category: Lipopolysaccharide export pathway]]
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[[Category: Lptc]]
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[[Category: Scottish structural proteomics facility]]
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[[Category: Sspf]]
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[[Category: Structural genomic]]
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[[Category: Transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 1 09:49:15 2010''
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Current revision

Crystal structure of LptC

PDB ID 3my2

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