2l1g

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{{Seed}}
 
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[[Image:2l1g.jpg|left|200px]]
 
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==RDC refined solution structure of the THAP zinc finger of THAP1 in complex with its 16bp RRM1 DNA target==
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The line below this paragraph, containing "STRUCTURE_2l1g", creates the "Structure Box" on the page.
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<StructureSection load='2l1g' size='340' side='right'caption='[[2l1g]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2l1g]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L1G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L1G FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2l1g| PDB=2l1g | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l1g OCA], [https://pdbe.org/2l1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l1g RCSB], [https://www.ebi.ac.uk/pdbsum/2l1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l1g ProSAT]</span></td></tr>
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</table>
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===RDC refined solution structure of the THAP zinc finger of THAP1 in complex with its 16bp RRM1 DNA target===
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== Disease ==
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[https://www.uniprot.org/uniprot/THAP1_HUMAN THAP1_HUMAN] Defects in THAP1 are the cause of dystonia type 6 (DYT6) [MIM:[https://omim.org/entry/602629 602629]. DYT6 is a primary torsion dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Dystonia type 6 is characterized by onset in early adulthood, cranial or cervical involvement in about half of the cases, and frequent progression to involve multiple body regions.[:]<ref>PMID:19345147</ref> <ref>PMID:19908325</ref> <ref>PMID:19908320</ref> <ref>PMID:19182804</ref> <ref>PMID:20629133</ref> <ref>PMID:20669277</ref> <ref>PMID:20687191</ref> <ref>PMID:20083799</ref> <ref>PMID:20211909</ref> <ref>PMID:21847143</ref> <ref>PMID:20825472</ref> <ref>PMID:21800139</ref> <ref>PMID:21839475</ref> <ref>PMID:21425335</ref> <ref>PMID:21425341</ref> <ref>PMID:21110056</ref> <ref>PMID:22377579</ref>
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== Function ==
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==About this Structure==
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[https://www.uniprot.org/uniprot/THAP1_HUMAN THAP1_HUMAN] DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.<ref>PMID:12717420</ref> <ref>PMID:17003378</ref> <ref>PMID:20200153</ref>
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2L1G is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L1G OCA].
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l1/2l1g_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2l1g ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Campagne, S.]]
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[[Category: Large Structures]]
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[[Category: Gervais, V.]]
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[[Category: Campagne S]]
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[[Category: Milon, A.]]
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[[Category: Gervais V]]
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[[Category: Saurel, O.]]
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[[Category: Milon A]]
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[[Category: Ccch]]
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[[Category: Saurel O]]
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[[Category: Dna binding domain]]
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[[Category: Protein-dna complex]]
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[[Category: Transcription factor]]
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[[Category: Transcription-dna complex]]
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[[Category: Zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Sep 10 13:52:50 2010''
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Current revision

RDC refined solution structure of the THAP zinc finger of THAP1 in complex with its 16bp RRM1 DNA target

PDB ID 2l1g

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