3jq4

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[[Image:3jq4.jpg|left|200px]]
 
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==The structure of the complex of the large ribosomal subunit from D. Radiodurans with the antibiotic lankacidin==
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The line below this paragraph, containing "STRUCTURE_3jq4", creates the "Structure Box" on the page.
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<StructureSection load='3jq4' size='340' side='right'caption='[[3jq4]], [[Resolution|resolution]] 3.52&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3jq4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans_R1 Deinococcus radiodurans R1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JQ4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.52&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LC2:N-[(1S,2R,3E,5E,7S,9E,11E,13S,15R,19R)-7,13-DIHYDROXY-1,4,10,19-TETRAMETHYL-17,18-DIOXO-16-OXABICYCLO[13.2.2]NONADECA-3,5,9,11-TETRAEN-2-YL]-2-OXOPROPANAMIDE'>LC2</scene></td></tr>
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{{STRUCTURE_3jq4| PDB=3jq4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jq4 OCA], [https://pdbe.org/3jq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jq4 RCSB], [https://www.ebi.ac.uk/pdbsum/3jq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jq4 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Crystallographic analysis revealed that the 17-member polyketide antibiotic lankacidin produced by Streptomyces rochei binds at the peptidyl transferase center of the eubacterial large ribosomal subunit. Biochemical and functional studies verified this finding and showed interference with peptide bond formation. Chemical probing indicated that the macrolide lankamycin, a second antibiotic produced by the same species, binds at a neighboring site, at the ribosome exit tunnel. These two antibiotics can bind to the ribosome simultaneously and display synergy in inhibiting bacterial growth. The binding site of lankacidin and lankamycin partially overlap with the binding site of another pair of synergistic antibiotics, the streptogramins. Thus, at least two pairs of structurally dissimilar compounds have been selected in the course of evolution to act synergistically by targeting neighboring sites in the ribosome. These results underscore the importance of the corresponding ribosomal sites for development of clinically relevant synergistic antibiotics and demonstrate the utility of structural analysis for providing new directions for drug discovery.
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===The structure of the complex of the large ribosomal subunit from D. Radiodurans with the antibiotic lankacidin===
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The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics.,Auerbach T, Mermershtain I, Davidovich C, Bashan A, Belousoff M, Wekselman I, Zimmerman E, Xiong L, Klepacki D, Arakawa K, Kinashi H, Mankin AS, Yonath A Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):1983-8. Epub 2010 Jan 11. PMID:20080686<ref>PMID:20080686</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3jq4" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20080686 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20080686}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Deinococcus radiodurans R1]]
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3JQ4 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JQ4 OCA].
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[[Category: Large Structures]]
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[[Category: Auerbach-Nevo T]]
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==Reference==
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[[Category: Bashan A]]
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<ref group="xtra">PMID:20080686</ref><references group="xtra"/>
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[[Category: Davidovich C]]
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[[Category: Deinococcus radiodurans]]
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[[Category: Mermershtain I]]
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[[Category: Ada, Y.]]
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[[Category: Rozenberg H]]
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[[Category: Anat, B.]]
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[[Category: Yonath A]]
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[[Category: Chen, D.]]
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[[Category: Haim, R.]]
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[[Category: Inbal, M.]]
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[[Category: Tamar, A N.]]
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[[Category: Antibiotic]]
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[[Category: Inhibitor]]
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[[Category: Lankacidin]]
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[[Category: Lankamycin]]
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[[Category: Macrolide]]
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[[Category: Protein synthesis]]
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[[Category: Ribosome structure]]
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[[Category: Rna]]
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[[Category: Synergism]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Sep 10 13:56:46 2010''
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Current revision

The structure of the complex of the large ribosomal subunit from D. Radiodurans with the antibiotic lankacidin

PDB ID 3jq4

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