Sandbox c1

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-	==This is a placeholder==	+	<Structure load='1ACJ' size='500' frame='true' align='right' caption='Insert caption here' />
-	This is a placeholder text to help you get started in	+	1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.
-	placing a Jmol applet on your page. At any time, click	+
-	"Show Preview" at the bottom of this page to see how it goes.	+
-	Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load	+	Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor.
-	and display another structure.	+
-	{{STRUCTURE_3cin | PDB=3cin | SCENE= }}	+	It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease.
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		+	Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 (W84 and F330).
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		+	<scene name='Sandbox_c1/Sitio_activo/1'>(W84 and F330)</scene><ref>PMID:8415649</ref>
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		+	Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues. in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649.<references/>
		+	===How do we get the oxygen we breathe?===
		+	Oxygen is required by all aerobic animals as a basic mechanism to accept electrons and hydrogen ions produced during metabolism. Even when oxygen is all around us, in the air and in the water, oxygen need to be close to the cells where it's going to be used.

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Current revision

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1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.

Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor.

It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease.

Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 (W84 and F330).

^[1]

Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues. in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649.

1. ↑ Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649

How do we get the oxygen we breathe?

Oxygen is required by all aerobic animals as a basic mechanism to accept electrons and hydrogen ions produced during metabolism. Even when oxygen is all around us, in the air and in the water, oxygen need to be close to the cells where it's going to be used.