Sandbox c5

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-	==This is a placeholder==	+	<Structure load='1acj' size='500' frame='true' align='right' caption='estructura favorita' />1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.
-	This is a placeholder text to help you get started in	+
-	placing a Jmol applet on your page. At any time, click	+
-	"Show Preview" at the bottom of this page to see how it goes.	+
-	Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load	+	Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor.
-	and display another structure.	+
-	{{STRUCTURE_1zt3 | PDB=1zt3 | SCENE= }}	+	It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease.
		+
		+	Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 .
		+
		+	<scene name='Sandbox_c5/Tacrine1/1'>(W84 and F330)</scene>
		+	<ref>PIMID 8415649</ref>
		+	Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649
		+	<references/>

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Current revision

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1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.

Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor.

It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease.

Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 .

^[1] Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649

1. ↑ PIMID 8415649