Sandbox c1

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-	{{Seed}}	+	<Structure load='1ACJ' size='500' frame='true' align='right' caption='Insert caption here' />
-	[[Image:1xbn.png|left|200px]]	+	1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.
-	<!--	+	Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor.
-	The line below this paragraph, containing "STRUCTURE_1xbn", creates the "Structure Box" on the page.	+
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)	+
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),	+
-	or leave the SCENE parameter empty for the default display.	+
-	-->	+
-	{{STRUCTURE_1xbn| PDB=1xbn | SCENE= }}	+
-	===Crystal structure of a bacterial nitric oxide sensor: an ortholog of mammalian soluble guanylate cyclase heme domain===	+	It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease.
		+	Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 (W84 and F330).
-	<!--	+	<scene name='Sandbox_c1/Sitio_activo/1'>(W84 and F330)</scene><ref>PMID:8415649</ref>
-	The line below this paragraph, {{ABSTRACT_PUBMED_15472039}}, adds the Publication Abstract to the page	+
-	(as it appears on PubMed at http://www.pubmed.gov), where 15472039 is the PubMed ID number.	+
-	-->	+
-	{{ABSTRACT_PUBMED_15472039}}	+
-	==About this Structure==
-	1XBN is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Thermoanaerobacter_tengcongensis Thermoanaerobacter tengcongensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XBN OCA].
-	==Reference==
-	<ref group="xtra">PMID:15472039</ref><references group="xtra"/>
-	[[Category: Thermoanaerobacter tengcongensis]]
-	[[Category: Nioche, P.]]
-	[[Category: Raman, C S.]]
-	[[Category: Cgmp]]
-	[[Category: Heme protein]]
-	[[Category: Nitric oxide]]
-	[[Category: Soluble guanylyl cyclase]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:48:42 2009''	+	Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues. in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649.<references/>
		+	===How do we get the oxygen we breathe?===
		+	Oxygen is required by all aerobic animals as a basic mechanism to accept electrons and hydrogen ions produced during metabolism. Even when oxygen is all around us, in the air and in the water, oxygen need to be close to the cells where it's going to be used.

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Current revision

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1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.

Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor.

It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease.

Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 (W84 and F330).

^[1]

Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues. in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649.

1. ↑ Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649

How do we get the oxygen we breathe?

Oxygen is required by all aerobic animals as a basic mechanism to accept electrons and hydrogen ions produced during metabolism. Even when oxygen is all around us, in the air and in the water, oxygen need to be close to the cells where it's going to be used.