2l33

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(New page: '''Unreleased structure''' The entry 2l33 is ON HOLD Authors: Liu, G., Janjua, H., Xiao, R., Acton, T.B., Ciccosanti, A., Shastry, R.B., Everett, J., Montelione, G.T., Northeast Structu...)
Current revision (05:38, 15 May 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 2l33 is ON HOLD
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==Solution NMR Structure of DRBM 2 domain of Interleukin enhancer-binding factor 3 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4527E==
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<StructureSection load='2l33' size='340' side='right'caption='[[2l33]]' scene=''>
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Authors: Liu, G., Janjua, H., Xiao, R., Acton, T.B., Ciccosanti, A., Shastry, R.B., Everett, J., Montelione, G.T., Northeast Structural Genomics Consortium, n.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2l33]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L33 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L33 FirstGlance]. <br>
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Description: Solution NMR Structure of DRBM 2 domain of Interleukin enhancer-binding factor 3 from homo sapiens, Northeast Structural Genomics Consortium Target HR4527E
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l33 OCA], [https://pdbe.org/2l33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l33 RCSB], [https://www.ebi.ac.uk/pdbsum/2l33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l33 ProSAT]</span></td></tr>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 15 10:27:12 2010''
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ILF3_HUMAN ILF3_HUMAN] May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can regulate protein arginine N-methyltransferase 1 activity. May regulate transcription of the IL2 gene during T-cell activation. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. The phosphorylated form at Thr-188 and Thr-315, in concert with EIF2AK2/PKR can inhibit vesicular stomatitis virus (VSV) replication (By similarity).<ref>PMID:7519613</ref> <ref>PMID:9442054</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l3/2l33_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2l33 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Acton TB]]
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[[Category: Ciccosanti A]]
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[[Category: Everett J]]
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[[Category: Janjua H]]
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[[Category: Liu G]]
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[[Category: Montelione GT]]
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[[Category: Structural genomic]]
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[[Category: Shastry RB]]
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[[Category: Xiao R]]

Current revision

Solution NMR Structure of DRBM 2 domain of Interleukin enhancer-binding factor 3 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4527E

PDB ID 2l33

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