2vac

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[[Image:2vac.gif|left|200px]]<br /><applet load="2vac" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2vac, resolution 1.70&Aring;" />
 
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'''STRUCTURE OF N-TERMINAL ACTIN DEPOLYMERIZING FACTOR HOMOLOGY (ADF-H) DOMAIN OF HUMAN TWINFILIN-2'''<br />
 
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==About this Structure==
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==Structure of N-terminal Actin Depolymerizing Factor homology (ADF-H) domain of human twinfilin-2==
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2VAC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN and EDO as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Edo Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2VAC OCA].
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<StructureSection load='2vac' size='340' side='right'caption='[[2vac]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[2vac]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VAC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VAC FirstGlance]. <br>
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[[Category: Arrowsmith, C.H.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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[[Category: Delft, F.Von.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Edwards, A.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vac OCA], [https://pdbe.org/2vac PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vac RCSB], [https://www.ebi.ac.uk/pdbsum/2vac PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vac ProSAT]</span></td></tr>
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[[Category: Elkins, J.M.]]
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</table>
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[[Category: King, O.]]
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== Function ==
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[[Category: Knapp, S.]]
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[https://www.uniprot.org/uniprot/TWF2_HUMAN TWF2_HUMAN] Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity).
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[[Category: Pike, A.C.W.]]
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== Evolutionary Conservation ==
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[[Category: Salah, E.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Savitsky, P.]]
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Check<jmol>
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[[Category: Sundstrom, M.]]
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<jmolCheckbox>
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[[Category: Weigelt, J.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/va/2vac_consurf.spt"</scriptWhenChecked>
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[[Category: EDO]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: ZN]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: actin binding]]
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</jmolCheckbox>
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[[Category: actin depolymerizing factor transferase]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vac ConSurf].
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[[Category: actin-binding]]
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<div style="clear:both"></div>
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[[Category: cofilin-like]]
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[[Category: cytoplasm]]
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[[Category: cytoskeleton]]
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[[Category: phosphorylation]]
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[[Category: protein tyrosine kinase-9]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 20:33:52 2007''
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==See Also==
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*[[Twinfilin|Twinfilin]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Edwards A]]
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[[Category: Elkins JM]]
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[[Category: King O]]
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[[Category: Knapp S]]
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[[Category: Pike ACW]]
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[[Category: Salah E]]
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[[Category: Savitsky P]]
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[[Category: Sundstrom M]]
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[[Category: Weigelt J]]
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[[Category: Von Delft F]]

Current revision

Structure of N-terminal Actin Depolymerizing Factor homology (ADF-H) domain of human twinfilin-2

PDB ID 2vac

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