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3oob
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3oob is ON HOLD Authors: Urusova, D.V., Shim, J.-H., Kim, D.-J., Jung, S.K., Zykova, T.A., Bode, A.M., Dong, Z. Description: Structural and functio...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structural and functional insights of directly targeting Pin1 by Epigallocatechin-3-gallate== | |
| + | <StructureSection load='3oob' size='340' side='right'caption='[[3oob]], [[Resolution|resolution]] 1.89Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3oob]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OOB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OOB FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KDH:(2R,3R)-5,7-DIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-3,4-DIHYDRO-2H-CHROMEN-3-YL+3,4,5-TRIHYDROXYBENZOATE'>KDH</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oob OCA], [https://pdbe.org/3oob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oob RCSB], [https://www.ebi.ac.uk/pdbsum/3oob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oob ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Peptidyl-prolyl cis-trans isomerase 3D structures|Peptidyl-prolyl cis-trans isomerase 3D structures]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bode AM]] | ||
| + | [[Category: Dong Z]] | ||
| + | [[Category: Jung SK]] | ||
| + | [[Category: Kim D-J]] | ||
| + | [[Category: Shim J-H]] | ||
| + | [[Category: Urusova DV]] | ||
| + | [[Category: Zykova TA]] | ||
Current revision
Structural and functional insights of directly targeting Pin1 by Epigallocatechin-3-gallate
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Categories: Homo sapiens | Large Structures | Bode AM | Dong Z | Jung SK | Kim D-J | Shim J-H | Urusova DV | Zykova TA
