3oom

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(New page: '''Unreleased structure''' The entry 3oom is ON HOLD Authors: Chaikuad, A., Sanvitale, C., Cooper, C., Mahajan, P., Daga, N., Petrie, K., Alfano, I., Gileadi, O., Fedorov, O., Allerston...)
Current revision (16:56, 1 November 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 3oom is ON HOLD
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==Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00507==
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<StructureSection load='3oom' size='340' side='right'caption='[[3oom]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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Authors: Chaikuad, A., Sanvitale, C., Cooper, C., Mahajan, P., Daga, N., Petrie, K., Alfano, I., Gileadi, O., Fedorov, O., Allerston, C., Krojer, T., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consort
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3oom]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OOM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OOM FirstGlance]. <br>
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Description: Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00507
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=507:1-{3-[6-(TETRAHYDRO-2H-PYRAN-4-YLAMINO)IMIDAZO[1,2-B]PYRIDAZIN-3-YL]PHENYL}ETHANONE'>507</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 15 10:38:07 2010''
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oom OCA], [https://pdbe.org/3oom PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oom RCSB], [https://www.ebi.ac.uk/pdbsum/3oom PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oom ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ACVR1_HUMAN ACVR1_HUMAN] Fibrodysplasia ossificans progressiva. Defects in ACVR1 are a cause of fibrodysplasia ossificans progressiva (FOP) [MIM:[https://omim.org/entry/135100 135100]. FOP is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. Heterotopic ossification in FOP begins in childhood and can be induced by trauma or may occur without warning. Bone formation is episodic and progressive, leading to extra-articular ankylosis of all major joints of the axial and appendicular skeleton, rendering movement impossible.<ref>PMID:16642017</ref> <ref>PMID:19085907</ref> <ref>PMID:19330033</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ACVR1_HUMAN ACVR1_HUMAN] On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Alfano I]]
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[[Category: Allerston C]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra C]]
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[[Category: Bullock A]]
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[[Category: Chaikuad A]]
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[[Category: Cooper C]]
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[[Category: Daga N]]
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[[Category: Edwards AM]]
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[[Category: Fedorov O]]
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[[Category: Gileadi O]]
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[[Category: Krojer T]]
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[[Category: Mahajan P]]
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[[Category: Petrie K]]
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[[Category: Sanvitale C]]
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[[Category: Weigelt J]]
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[[Category: Von Delft F]]

Current revision

Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00507

PDB ID 3oom

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