3oq4
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3oq4 is ON HOLD Authors: Matthews, L.A., Jones, D.R., Prasad, A.A., Duncker, B.P., Guarne, A. Description: Crystal Structure of motif N of Saccharo...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of motif N of Saccharomyces cerevisiae Dbf4== | |
| - | + | <StructureSection load='3oq4' size='340' side='right'caption='[[3oq4]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3oq4]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OQ4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oq4 OCA], [https://pdbe.org/3oq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oq4 RCSB], [https://www.ebi.ac.uk/pdbsum/3oq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oq4 ProSAT]</span></td></tr> | |
| - | '' | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DBF4_YEAST DBF4_YEAST] Regulatory subunit of the CDC7-DBF4 kinase, also called DBF4-dependent kinase (DDK), which is involved in cell cycle regulation of premitotic and premeiotic chromosome replication and in chromosome segregation. DDK plays an essential role in initiating DNA replication at replication origins by phosphorylating the MCM2 and MCM4 subunits of the MCM2-7 helicase complex. DBF4 recruits the catalytic subunit CDC7 to MCM2 and to origins of replication. DDK has also postreplicative functions in meiosis. DDK phosphorylates the meiosis-specific double-strand break protein MER2 for initiation of meiotic recombination. Interacts with CDC5 during meiosis to promote double-strand breaks and monopolar spindle orientation. Inhibits CDC5 activity during mitosis through direct binding to its PBD.<ref>PMID:8066465</ref> <ref>PMID:12441400</ref> <ref>PMID:16319063</ref> <ref>PMID:17018296</ref> <ref>PMID:19013276</ref> <ref>PMID:18245450</ref> <ref>PMID:19692334</ref> <ref>PMID:19478884</ref> <ref>PMID:20436286</ref> <ref>PMID:21036905</ref> <ref>PMID:20170732</ref> <ref>PMID:20054399</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Saccharomyces cerevisiae]] | ||
| + | [[Category: Duncker BP]] | ||
| + | [[Category: Guarne A]] | ||
| + | [[Category: Jones DR]] | ||
| + | [[Category: Matthews LA]] | ||
| + | [[Category: Prasad AA]] | ||
Current revision
Crystal Structure of motif N of Saccharomyces cerevisiae Dbf4
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