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2l0e

From Proteopedia

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{{Seed}}
 
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[[Image:2l0e.jpg|left|200px]]
 
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==Structural and functional analysis of tm vi of the nhe1 isoform of the na+/h+ exchanger==
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The line below this paragraph, containing "STRUCTURE_2l0e", creates the "Structure Box" on the page.
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<StructureSection load='2l0e' size='340' side='right'caption='[[2l0e]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2l0e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L0E FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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{{STRUCTURE_2l0e| PDB=2l0e | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l0e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l0e OCA], [https://pdbe.org/2l0e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l0e RCSB], [https://www.ebi.ac.uk/pdbsum/2l0e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l0e ProSAT]</span></td></tr>
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</table>
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===Structural and functional analysis of tm vi of the nhe1 isoform of the na+/h+ exchanger===
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== Function ==
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[https://www.uniprot.org/uniprot/SL9A1_HUMAN SL9A1_HUMAN] Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.<ref>PMID:8901634</ref> <ref>PMID:11350981</ref> <ref>PMID:15035633</ref>
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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2L0E is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0E OCA].
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Check<jmol>
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[[Category: Fliegel, L.]]
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<jmolCheckbox>
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[[Category: Lee, B L.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l0/2l0e_consurf.spt"</scriptWhenChecked>
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[[Category: Sykes, B D.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Tzeng, J.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Membrane protein]]
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</jmolCheckbox>
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[[Category: Nhe1]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2l0e ConSurf].
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[[Category: Transmembrane helix]]
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<div style="clear:both"></div>
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== References ==
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 15 10:45:18 2010''
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Fliegel L]]
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[[Category: Lee BL]]
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[[Category: Sykes BD]]
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[[Category: Tzeng J]]

Current revision

Structural and functional analysis of tm vi of the nhe1 isoform of the na+/h+ exchanger

PDB ID 2l0e

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