1eur

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[[Image:1eur.gif|left|200px]]<br />
 
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<applet load="1eur" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1eur, resolution 1.82&Aring;" />
 
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'''SIALIDASE'''<br />
 
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==Overview==
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==SIALIDASE==
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BACKGROUND: Sialidases, or neuraminidases, have been implicated in the, pathogenesis of many diseases, but are also produced by many, non-pathogenic bacteria. Bacterial sialidases are very variable in size, often possessing domains in addition to the catalytic domain. The, sialidase from the non-pathogenic soil bacterium Micromonospora, viridifaciens is secreted in two forms with molecular weights of 41 kDa or, 68 kDa, depending on the nature of the carbohydrate used to induce, expression. RESULTS: We report here the X-ray crystal structures of the 41, kDa and 68 kDa forms of the sialidase from M. viridifaciens at 1.8 A and, 2.5 A resolution respectively. In addition, we report a complex of the 41, kDa form with an inhibitor at 2.0 A resolution, and a complex of the 68, kDa form with ... [[http://ispc.weizmann.ac.il/pmbin/getpm?8591030 (full description)]]
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<StructureSection load='1eur' size='340' side='right'caption='[[1eur]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1eur]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Micromonospora_viridifaciens Micromonospora viridifaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EUR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EUR FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1eur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eur OCA], [https://pdbe.org/1eur PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1eur RCSB], [https://www.ebi.ac.uk/pdbsum/1eur PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1eur ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NANH_MICVI NANH_MICVI] To release sialic acids for use as carbon and energy sources for this non-pathogenic bacterium while in pathogenic microorganisms, sialidases have been suggested to be pathogenic factors.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eu/1eur_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1eur ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1EUR is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Micromonospora_viridifaciens Micromonospora viridifaciens]]. Active as [[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18]]. Structure known Active Site: ACT. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1EUR OCA]].
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*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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The three domains of a bacterial sialidase: a beta-propeller, an immunoglobulin module and a galactose-binding jelly-roll., Gaskell A, Crennell S, Taylor G, Structure. 1995 Nov 15;3(11):1197-205. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8591030 8591030]
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[[Category: Large Structures]]
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[[Category: Exo-alpha-sialidase]]
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[[Category: Micromonospora viridifaciens]]
[[Category: Micromonospora viridifaciens]]
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[[Category: Single protein]]
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[[Category: Crennell SJ]]
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[[Category: Crennell, S.J.]]
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[[Category: Gaskell A]]
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[[Category: Gaskell, A.]]
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[[Category: Taylor GL]]
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[[Category: Taylor, G.L.]]
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[[Category: hydrolase]]
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[[Category: neuraminidase]]
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[[Category: sialidase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:57:20 2007''
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Current revision

SIALIDASE

PDB ID 1eur

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