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3k3p

From Proteopedia

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{{Seed}}
 
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[[Image:3k3p.jpg|left|200px]]
 
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==Crystal Structure of the Apo Form of D-Alanine:D-Alanine Ligase (DDl) from Streptococcus mutans==
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The line below this paragraph, containing "STRUCTURE_3k3p", creates the "Structure Box" on the page.
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<StructureSection load='3k3p' size='340' side='right'caption='[[3k3p]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3k3p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K3P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K3P FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.23&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k3p OCA], [https://pdbe.org/3k3p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k3p RCSB], [https://www.ebi.ac.uk/pdbsum/3k3p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k3p ProSAT]</span></td></tr>
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{{STRUCTURE_3k3p| PDB=3k3p | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DDL_STRMU DDL_STRMU] Cell wall formation (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k3/3k3p_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3k3p ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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D-Alanine:D-Alanine ligase (DDl) catalyzes the formation of D-Alanine:D-Alanine dipeptide and is an essential enzyme in bacterial cell wall biosynthesis.. This enzyme does not have a human ortholog, making it an attractive target for developing new antibiotic drugs. We determined the crystal structure at 2.23 A resolution of DDl from Streptococcus mutans (SmDDl), the principal aetiological agent of human dental caries. This structure reveals that SmDDl is a dimer and has a disordered omega-loop region.
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===Crystal Structure of the Apo Form of D-Alanine:D-Alanine Ligase (DDl) from Streptococcus mutans===
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Crystal structure of the Apo form of D-Alanine:D-Alanine ligase (DDl) from Streptococcus mutans.,Lu Y, Xu H, Zhao X Protein Pept Lett. 2010;17(8):1053-7. PMID:20522004<ref>PMID:20522004</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3k3p" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_20522004}}, adds the Publication Abstract to the page
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*[[D-alanine-D-alanine ligase 3D structures|D-alanine-D-alanine ligase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 20522004 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20522004}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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3K3P is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K3P OCA].
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==Reference==
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<ref group="xtra">PMID:20522004</ref><references group="xtra"/>
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[[Category: D-alanine--D-alanine ligase]]
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[[Category: Streptococcus mutans]]
[[Category: Streptococcus mutans]]
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[[Category: Lu, Y.]]
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[[Category: Lu Y]]
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[[Category: Atp-binding]]
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[[Category: Cell shape]]
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[[Category: Cell wall biogenesis/degradation]]
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[[Category: D-alanyl-alanine synthetase]]
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[[Category: Ligase]]
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[[Category: Magnesium]]
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[[Category: Manganese]]
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[[Category: Metal-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: Peptidoglycan synthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 15 10:48:29 2010''
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Current revision

Crystal Structure of the Apo Form of D-Alanine:D-Alanine Ligase (DDl) from Streptococcus mutans

PDB ID 3k3p

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