3kfx

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{{Seed}}
 
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[[Image:3kfx.jpg|left|200px]]
 
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==Human dCK complex with 5-Me dC and ADP==
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The line below this paragraph, containing "STRUCTURE_3kfx", creates the "Structure Box" on the page.
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<StructureSection load='3kfx' size='340' side='right'caption='[[3kfx]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3kfx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KFX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KFX FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MCY:5-METHYL-2-DEOXYCYTIDINE'>MCY</scene></td></tr>
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{{STRUCTURE_3kfx| PDB=3kfx | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kfx OCA], [https://pdbe.org/3kfx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kfx RCSB], [https://www.ebi.ac.uk/pdbsum/3kfx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kfx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kf/3kfx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kfx ConSurf].
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<div style="clear:both"></div>
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===Human dCK complex with 5-Me dC and ADP===
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==See Also==
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*[[Deoxycytidine kinase 3D structures|Deoxycytidine kinase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 20614893 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_20614893}}
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==About this Structure==
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3KFX is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KFX OCA].
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==Reference==
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<ref group="xtra">PMID:20614893</ref><references group="xtra"/>
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[[Category: Deoxycytidine kinase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hazra, S.]]
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[[Category: Large Structures]]
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[[Category: Lavie, A.]]
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[[Category: Hazra S]]
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[[Category: 5-me dc]]
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[[Category: Lavie A]]
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[[Category: Atp-binding]]
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[[Category: Human dck]]
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[[Category: Kinase]]
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[[Category: Nucleotide kinase]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleus]]
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[[Category: P-loop]]
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[[Category: Phosphoprotein]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 15 10:48:34 2010''
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Current revision

Human dCK complex with 5-Me dC and ADP

PDB ID 3kfx

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OCA

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