3nkv

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{{Seed}}
 
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[[Image:3nkv.png|left|200px]]
 
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==Crystal structure of Rab1b covalently modified with AMP at Y77==
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The line below this paragraph, containing "STRUCTURE_3nkv", creates the "Structure Box" on the page.
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<StructureSection load='3nkv' size='340' side='right'caption='[[3nkv]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3nkv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NKV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_3nkv| PDB=3nkv | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nkv OCA], [https://pdbe.org/3nkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nkv RCSB], [https://www.ebi.ac.uk/pdbsum/3nkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nkv ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nk/3nkv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3nkv ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In the course of Legionnaires' disease, the bacterium Legionella pneumophila affects the intracellular vesicular trafficking of infected eukaryotic cells by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole. In order to accomplish this, the Legionella protein DrrA contains a specific guanine nucleotide exchange activity for Rab1 activation that exchanges guanosine triphosphate (GTP) for guanosine diphosphate on Rab1. We found that the amino-terminal domain of DrrA possesses adenosine monophosphorylation (AMPylation) activity toward the switch II region of Rab1b, leading to posttranslational covalent modification of tyrosine 77. AMPylation of switch II by DrrA restricts the access of GTPase activating proteins, thereby rendering Rab1b constitutively active.
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===Crystal structure of Rab1b covalently modified with AMP at Y77===
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The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b.,Muller MP, Peters H, Blumer J, Blankenfeldt W, Goody RS, Itzen A Science. 2010 Aug 20;329(5994):946-9. Epub 2010 Jul 22. PMID:20651120<ref>PMID:20651120</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3nkv" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_20651120}}, adds the Publication Abstract to the page
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*[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 20651120 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20651120}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3NKV is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NKV OCA].
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==Reference==
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<ref group="xtra">PMID:20651120</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Blankenfeldt, W.]]
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[[Category: Large Structures]]
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[[Category: Goody, R S.]]
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[[Category: Blankenfeldt W]]
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[[Category: Itzen, A.]]
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[[Category: Goody RS]]
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[[Category: Mueller, M P.]]
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[[Category: Itzen A]]
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[[Category: Peters, H.]]
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[[Category: Mueller MP]]
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[[Category: Adenylylation]]
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[[Category: Peters H]]
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[[Category: Ampylation]]
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[[Category: Posttranslational modification]]
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[[Category: Protein transport]]
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[[Category: Rab1b]]
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[[Category: Vesicular transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 14:20:47 2010''
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Current revision

Crystal structure of Rab1b covalently modified with AMP at Y77

PDB ID 3nkv

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