1bfe

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{{Seed}}
 
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[[Image:1bfe.png|left|200px]]
 
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==THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95==
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The line below this paragraph, containing "STRUCTURE_1bfe", creates the "Structure Box" on the page.
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<StructureSection load='1bfe' size='340' side='right'caption='[[1bfe]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1bfe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BFE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BFE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bfe OCA], [https://pdbe.org/1bfe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bfe RCSB], [https://www.ebi.ac.uk/pdbsum/1bfe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bfe ProSAT]</span></td></tr>
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{{STRUCTURE_1bfe| PDB=1bfe | SCENE= }}
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</table>
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== Function ==
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===THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95===
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[https://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_8674113}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 8674113 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bf/1bfe_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_8674113}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bfe ConSurf].
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1BFE is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BFE OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:8674113</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Doyle, D A.]]
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[[Category: Doyle DA]]
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[[Category: Kim, E.]]
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[[Category: Kim E]]
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[[Category: Lee, A.]]
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[[Category: Lee A]]
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[[Category: Lewis, J.]]
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[[Category: Lewis J]]
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[[Category: Mackinnon, R.]]
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[[Category: Mackinnon R]]
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[[Category: Sheng, M.]]
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[[Category: Sheng M]]
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[[Category: Peptide recognition]]
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[[Category: Protein localization]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 14:24:18 2010''
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Current revision

THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95

PDB ID 1bfe

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