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2l38

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[[Image:2l38.jpg|left|200px]]
 
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==R29Q Sticholysin II mutant==
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The line below this paragraph, containing "STRUCTURE_2l38", creates the "Structure Box" on the page.
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<StructureSection load='2l38' size='340' side='right'caption='[[2l38]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2l38]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ks3 2ks3]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L38 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L38 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l38 OCA], [https://pdbe.org/2l38 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l38 RCSB], [https://www.ebi.ac.uk/pdbsum/2l38 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l38 ProSAT]</span></td></tr>
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{{STRUCTURE_2l38| PDB=2l38 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACTP2_STIHL ACTP2_STIHL] Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers. Cytolytic effects include red blood cells hemolysis, platelet aggregation and lysis, cytotoxic and cytostatic effects on fibroblasts. Lethality in mammals has been ascribed to severe vasospasm of coronary vessels, cardiac arrhythmia, and inotropic effects.<ref>PMID:10978735</ref> <ref>PMID:11478962</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l3/2l38_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2l38 ConSurf].
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<div style="clear:both"></div>
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===R29Q Sticholysin II mutant===
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==See Also==
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*[[Cytolysin 3D structures|Cytolysin 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2L38 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ks3 2ks3]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L38 OCA].
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Stichodactyla helianthus]]
[[Category: Stichodactyla helianthus]]
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[[Category: Alegre-Cebollada, J.]]
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[[Category: Alegre-Cebollada J]]
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[[Category: Bruix, M.]]
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[[Category: Bruix M]]
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[[Category: Castrillo, I.]]
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[[Category: Castrillo I]]
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[[Category: Gavilanes, J.]]
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[[Category: Gavilanes J]]
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[[Category: Martinez-del-Pozo, A.]]
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[[Category: Martinez-del-Pozo A]]
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[[Category: Actinoporin]]
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[[Category: Pore forming toxin]]
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[[Category: Sticholysin]]
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[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 14:39:12 2010''
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Current revision

R29Q Sticholysin II mutant

PDB ID 2l38

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