3bg0

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(New page: 200px<br /><applet load="3bg0" size="450" color="white" frame="true" align="right" spinBox="true" caption="3bg0, resolution 3.15&Aring;" /> '''The Structure of the...)
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[[Image:3bg0.jpg|left|200px]]<br /><applet load="3bg0" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="3bg0, resolution 3.15&Aring;" />
 
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'''The Structure of the p62 Complex'''<br />
 
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==Overview==
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==Architecture of a Coat for the Nuclear Pore Membrane==
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The symmetric core of the nuclear pore complex can be considered, schematically as a series of concentric cylinders. A peripheral cylinder, coating the pore membrane contains the previously characterized, elongated, heptamer that harbors Sec13-Nup145C in its middle section. Strikingly, Sec13-Nup145C crystallizes as a hetero-octamer in two space groups., Oligomerization of Sec13-Nup145C was confirmed biochemically. Importantly, the numerous interacting surfaces in the hetero-octamer are evolutionarily, highly conserved, further underlining the physiological relevance of the, oligomerization. The hetero-octamer forms a slightly curved, yet rigid rod, of sufficient length to span the entire height of the proposed, membrane-adjacent cylinder. In concordance with the dimensions and, symmetry of the nuclear pore complex core, we suggest that the cylinder is, constructed of four antiparallel rings, each ring being composed of eight, heptamers arranged in a head-to-tail fashion. Our model proposes that the, hetero-octamer would vertically traverse and connect the four stacked, rings.
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<StructureSection load='3bg0' size='340' side='right'caption='[[3bg0]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3bg0]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BG0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BG0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.15&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bg0 OCA], [https://pdbe.org/3bg0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bg0 RCSB], [https://www.ebi.ac.uk/pdbsum/3bg0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bg0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SEC13_HUMAN SEC13_HUMAN] Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles.<ref>PMID:8972206</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bg/3bg0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bg0 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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3BG0 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=3BG0 OCA].
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*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
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== References ==
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==Reference==
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<references/>
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Architecture of a coat for the nuclear pore membrane., Hsia KC, Stavropoulos P, Blobel G, Hoelz A, Cell. 2007 Dec 28;131(7):1313-26. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18160040 18160040]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Hoelz, A.]]
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[[Category: Hoelz A]]
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[[Category: autocatalytic cleavage]]
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[[Category: hydrolase]]
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[[Category: mrna transport]]
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[[Category: npc]]
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[[Category: nuclear pore complex]]
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[[Category: nucleus]]
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[[Category: phosphoprotein]]
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[[Category: protein transport]]
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[[Category: rna-binding]]
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[[Category: translocation]]
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[[Category: transport]]
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[[Category: wd repeat]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Jan 14 18:23:05 2008''
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Current revision

Architecture of a Coat for the Nuclear Pore Membrane

PDB ID 3bg0

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