1nwz

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{{Seed}}
 
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[[Image:1nwz.png|left|200px]]
 
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==PYP Ultra-high resolution structure of a Bacterial Photoreceptor==
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The line below this paragraph, containing "STRUCTURE_1nwz", creates the "Structure Box" on the page.
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<StructureSection load='1nwz' size='340' side='right'caption='[[1nwz]], [[Resolution|resolution]] 0.82&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1nwz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Halorhodospira_halophila Halorhodospira halophila]. The March 2015 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Phototropin'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2015_3 10.2210/rcsb_pdb/mom_2015_3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NWZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.82&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HC4:4-HYDROXYCINNAMIC+ACID'>HC4</scene></td></tr>
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{{STRUCTURE_1nwz| PDB=1nwz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nwz OCA], [https://pdbe.org/1nwz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nwz RCSB], [https://www.ebi.ac.uk/pdbsum/1nwz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nwz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PYP_HALHA PYP_HALHA] Photoactive blue light protein. Probably functions as a photoreceptor for a negative phototaxis response.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nw/1nwz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nwz ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Protein photoreceptors use small-molecule cofactors called chromophores to detect light. Only under the influence of the receptors' active sites do these chromophores adopt spectral and photochemical properties that suit the receptors' functional requirements. This protein-induced change in chromophore properties is called photochemical tuning and is a prime example for the general--but poorly understood--process of chemical tuning through which proteins shape the reactivity of their active-site groups. Here we report the 0.82-A resolution X-ray structure of the bacterial light receptor photoactive yellow protein (PYP). The unusually precise structure reveals deviations from expected molecular geometries and anisotropic atomic displacements in the PYP active site. Our analysis of these deviations points directly to the intramolecular forces and active-site dynamics that tune the properties of PYP's chromophore to absorb blue light, suppress fluorescence, and favor the required light-driven double-bond isomerization.
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===PYP Ultra-high resolution structure of a Bacterial Photoreceptor===
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Anticipatory active-site motions and chromophore distortion prime photoreceptor PYP for light activation.,Getzoff ED, Gutwin KN, Genick UK Nat Struct Biol. 2003 Aug;10(8):663-8. PMID:12872160<ref>PMID:12872160</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12872160}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1nwz" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12872160 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12872160}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1NWZ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Halorhodospira_halophila Halorhodospira halophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWZ OCA].
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==Reference==
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<ref group="xtra">PMID:12872160</ref><references group="xtra"/>
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[[Category: Halorhodospira halophila]]
[[Category: Halorhodospira halophila]]
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[[Category: Genick, U K.]]
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[[Category: Large Structures]]
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[[Category: Getzoff, E D.]]
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[[Category: Phototropin]]
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[[Category: Gutwin, K N.]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Domains fold]]
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[[Category: Genick UK]]
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[[Category: Gaf]]
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[[Category: Getzoff ED]]
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[[Category: Lov]]
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[[Category: Gutwin KN]]
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[[Category: Pa]]
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[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 29 07:40:37 2010''
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Current revision

PYP Ultra-high resolution structure of a Bacterial Photoreceptor

PDB ID 1nwz

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