3n7l

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{{Seed}}
 
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[[Image:3n7l.png|left|200px]]
 
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==Crystal structure of botulinum neurotoxin serotype D/C VPI 5993 binding domain==
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The line below this paragraph, containing "STRUCTURE_3n7l", creates the "Structure Box" on the page.
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<StructureSection load='3n7l' size='340' side='right'caption='[[3n7l]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3n7l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N7L FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3n7l| PDB=3n7l | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n7l OCA], [https://pdbe.org/3n7l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n7l RCSB], [https://www.ebi.ac.uk/pdbsum/3n7l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n7l ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9LBR1_CLOBO Q9LBR1_CLOBO]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n7/3n7l_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n7l ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The botulinum neurotoxins (BoNTs) are the most potent protein toxins for humans. There are seven serotypes of BoNTs (A-G) based on a lack of cross antiserum neutralization. BoNTs utilize gangliosides as components of the host receptors for binding and entry into neurons. Members of BoNT/C and BoNT/D serotypes include mosaic toxins that are organized in D/C and C/D toxins. One D/C mosaic toxin, BoNT/D-South Africa (BoNT/D-SA), was not fully neutralized by immunization with BoNT serotype C or D, which stimulated this study. Here the crystal structures of the receptor binding domains of BoNT/C, BoNT/D, and BoNT/D-SA are presented. Biochemical and cell binding studies show that BoNT/C and BoNT/D-SA possess unique mechanisms for ganglioside binding. These studies provide new information about how the BoNTs can enter host cells as well as a basis for understanding the immunological diversity of these neurotoxins.
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===Crystal structure of botulinum neurotoxin serotype D/C VPI 5993 binding domain===
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Identification of a Unique Ganglioside Binding Loop within Botulinum Neurotoxins C and D-SA .,Karalewitz AP, Kroken AR, Fu Z, Baldwin MR, Kim JJ, Barbieri JT Biochemistry. 2010 Aug 23. PMID:20731382<ref>PMID:20731382</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_20731382}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3n7l" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20731382 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20731382}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3N7L is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7L OCA].
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==Reference==
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<ref group="xtra">PMID:20731382</ref><references group="xtra"/>
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[[Category: Clostridium botulinum]]
[[Category: Clostridium botulinum]]
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[[Category: Baldwin, M R.]]
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[[Category: Large Structures]]
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[[Category: Barbieri, J T.]]
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[[Category: Baldwin MR]]
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[[Category: Fu, Z.]]
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[[Category: Barbieri JT]]
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[[Category: Karalewitz, A.]]
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[[Category: Fu Z]]
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[[Category: Kim, J-J P.]]
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[[Category: Karalewitz A]]
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[[Category: Kroken, A.]]
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[[Category: Kim J-JP]]
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[[Category: Botulinum neurotoxin]]
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[[Category: Kroken A]]
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[[Category: Ganglioside binding loop]]
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[[Category: Hcr/d-sa]]
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[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 29 07:45:25 2010''
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Current revision

Crystal structure of botulinum neurotoxin serotype D/C VPI 5993 binding domain

PDB ID 3n7l

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