3k7e
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human ligand-free mature caspase-6== | |
| + | <StructureSection load='3k7e' size='340' side='right'caption='[[3k7e]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3k7e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K7E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K7E FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k7e OCA], [https://pdbe.org/3k7e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k7e RCSB], [https://www.ebi.ac.uk/pdbsum/3k7e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k7e ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. | ||
| - | + | ==See Also== | |
| - | + | *[[Caspase 3D structures|Caspase 3D structures]] | |
| - | + | *[[Caspase-6 and neurodegeneration|Caspase-6 and neurodegeneration]] | |
| - | + | *[[Molecular Playground/Caspase-6 and neurodegeneration|Molecular Playground/Caspase-6 and neurodegeneration]] | |
| - | + | *[[User:Kevin Buadlart Dagbay|User:Kevin Buadlart Dagbay]] | |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hardy JA]] | ||
| + | [[Category: Vaidya S]] | ||
Current revision
Crystal structure of human ligand-free mature caspase-6
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