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3oy8
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3oy8 is ON HOLD Authors: Blanchard, H, Collins, P.M Description: Crystal structure of human galectin-1 in complex with lactobionic acid ''Page see...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human galectin-1 in complex with lactobionic acid== | |
| + | <StructureSection load='3oy8' size='340' side='right'caption='[[3oy8]], [[Resolution|resolution]] 2.19Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3oy8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OY8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OY8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GCO:GLUCONIC+ACID'>GCO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oy8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oy8 OCA], [https://pdbe.org/3oy8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oy8 RCSB], [https://www.ebi.ac.uk/pdbsum/3oy8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oy8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LEG1_HUMAN LEG1_HUMAN] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.<ref>PMID:14617626</ref> <ref>PMID:18796645</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Galectin 3D structures|Galectin 3D structures]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Blanchard H]] | ||
| + | [[Category: Collins PM]] | ||
Current revision
Crystal structure of human galectin-1 in complex with lactobionic acid
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