2wyn

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{{Seed}}
 
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[[Image:2wyn.jpg|left|200px]]
 
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==Structure of family 37 trehalase from Escherichia coli in complex with a casuarine-6-O-a-D-glucoside analogue==
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The line below this paragraph, containing "STRUCTURE_2wyn", creates the "Structure Box" on the page.
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<StructureSection load='2wyn' size='340' side='right'caption='[[2wyn]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2wyn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WYN FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=LG9:(1R,2R,3R,6R,7R,7AR)-3,7-BIS(HYDROXYMETHYL)HEXAHYDRO-1H-PYRROLIZINE-1,2,6-TRIOL'>LG9</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2wyn| PDB=2wyn | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wyn OCA], [https://pdbe.org/2wyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wyn RCSB], [https://www.ebi.ac.uk/pdbsum/2wyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wyn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TREA_ECOLI TREA_ECOLI] Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system.[HAMAP-Rule:MF_01060]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wy/2wyn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wyn ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Two novel casuarine-6-alpha-D-glucoside analogues, as well as the parent compound, were synthesized and tested as inhibitors towards Chironomus riparius, mammalian pig kidney and Escherichia coli trehalases. Their potent and selective activity is promising for the development of new insecticides.
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===STRUCTURE OF FAMILY 37 TREHALASE FROM ESCHERICHIA COLI IN COMPLEX WITH A CASUARINE-6-O-A-D-GLUCOSIDE ANALOGUE===
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Casuarine-6-O-alpha-D-glucoside and its analogues are tight binding inhibitors of insect and bacterial trehalases.,Cardona F, Goti A, Parmeggiani C, Parenti P, Forcella M, Fusi P, Cipolla L, Roberts SM, Davies GJ, Gloster TM Chem Commun (Camb). 2010 Apr 21;46(15):2629-31. PMID:20461849<ref>PMID:20461849</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_20461849}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2wyn" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20461849 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20461849}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Escherichia coli K-12]]
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2WYN is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WYN OCA].
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[[Category: Large Structures]]
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[[Category: Cardona F]]
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==Reference==
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[[Category: Cipolla L]]
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<ref group="xtra">PMID:20461849</ref><references group="xtra"/>
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[[Category: Davies GJ]]
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[[Category: Alpha,alpha-trehalase]]
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[[Category: Forcella M]]
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[[Category: Escherichia coli]]
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[[Category: Fusi P]]
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[[Category: Cardona, F.]]
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[[Category: Gloster TM]]
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[[Category: Cipolla, L.]]
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[[Category: Goti A]]
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[[Category: Davies, G J.]]
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[[Category: Parenti P]]
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[[Category: Forcella, M.]]
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[[Category: Parmeggiani C]]
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[[Category: Fusi, P.]]
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[[Category: Roberts SM]]
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[[Category: Gloster, T M.]]
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[[Category: Goti, A.]]
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[[Category: Parenti, P.]]
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[[Category: Parmeggiani, C.]]
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[[Category: Roberts, S M.]]
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[[Category: Glycosidase]]
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[[Category: Glycoside hydrolase]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 29 08:09:58 2010''
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Current revision

Structure of family 37 trehalase from Escherichia coli in complex with a casuarine-6-O-a-D-glucoside analogue

PDB ID 2wyn

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