2xrf

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{{Seed}}
 
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[[Image:2xrf.jpg|left|200px]]
 
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==Crystal structure of human uridine phosphorylase 2==
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The line below this paragraph, containing "STRUCTURE_2xrf", creates the "Structure Box" on the page.
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<StructureSection load='2xrf' size='340' side='right'caption='[[2xrf]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2xrf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XRF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=URA:URACIL'>URA</scene></td></tr>
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{{STRUCTURE_2xrf| PDB=2xrf | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xrf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrf OCA], [https://pdbe.org/2xrf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xrf RCSB], [https://www.ebi.ac.uk/pdbsum/2xrf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xrf ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UPP2_HUMAN UPP2_HUMAN] Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xr/2xrf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xrf ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF HUMAN URIDINE PHOSPHORYLASE 2===
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==See Also==
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*[[Uridine phosphorylase 3D structures|Uridine phosphorylase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2XRF is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRF OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Uridine phosphorylase]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Berg, S Van Der.]]
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[[Category: Berglund H]]
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[[Category: Berglund, H.]]
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[[Category: Bountra C]]
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[[Category: Bountra, C.]]
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[[Category: Collins R]]
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[[Category: Collins, R.]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M.]]
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[[Category: Flodin S]]
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[[Category: Flodin, S.]]
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[[Category: Flores A]]
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[[Category: Flores, A.]]
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[[Category: Graslund S]]
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[[Category: Graslund, S.]]
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[[Category: Hammarstrom M]]
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[[Category: Hammarstrom, M.]]
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[[Category: Johansson I]]
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[[Category: Johansson, I.]]
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[[Category: Karlberg T]]
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[[Category: Karlberg, T.]]
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[[Category: Kol S]]
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[[Category: Kol, S.]]
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[[Category: Kotenyova T]]
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[[Category: Kotenyova, T.]]
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[[Category: Kouznetsova E]]
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[[Category: Kouznetsova, E.]]
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[[Category: Moche M]]
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[[Category: Moche, M.]]
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[[Category: Nordlund P]]
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[[Category: Nordlund, P.]]
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[[Category: Nyman T]]
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[[Category: Nyman, T.]]
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[[Category: Persson C]]
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[[Category: Persson, C.]]
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[[Category: Schuler H]]
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[[Category: Schuler, H.]]
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[[Category: Schutz P]]
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[[Category: Schutz, P.]]
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[[Category: Siponen MI]]
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[[Category: Siponen, M I.]]
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[[Category: Thorsell AG]]
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[[Category: Thorsell, A G.]]
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[[Category: Tresaugues L]]
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[[Category: Tresaugues, L.]]
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[[Category: Van Der Berg S]]
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[[Category: Wahlberg, E.]]
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[[Category: Wahlberg E]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Welin, M.]]
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[[Category: Welin M]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 29 08:11:18 2010''
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Current revision

Crystal structure of human uridine phosphorylase 2

PDB ID 2xrf

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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