3op3

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{{Seed}}
 
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[[Image:3op3.jpg|left|200px]]
 
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==Crystal Structure of Cell Division Cycle 25C Protein Isoform A from Homo sapiens==
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The line below this paragraph, containing "STRUCTURE_3op3", creates the "Structure Box" on the page.
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<StructureSection load='3op3' size='340' side='right'caption='[[3op3]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3op3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OP3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OP3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.63&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3op3| PDB=3op3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3op3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3op3 OCA], [https://pdbe.org/3op3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3op3 RCSB], [https://www.ebi.ac.uk/pdbsum/3op3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3op3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MPIP3_HUMAN MPIP3_HUMAN] Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity.<ref>PMID:8119945</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/op/3op3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3op3 ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of Cell Division Cycle 25C Protein Isoform A from Homo sapiens===
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==See Also==
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*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
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==About this Structure==
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== References ==
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3OP3 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OP3 OCA].
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Ball, L.]]
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[[Category: Ball L]]
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[[Category: Barr, A.]]
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[[Category: Barr A]]
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[[Category: Bountra, C.]]
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[[Category: Bountra C]]
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[[Category: Delft, F von.]]
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[[Category: Edwards A]]
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[[Category: Edwards, A.]]
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[[Category: Gileadi O]]
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[[Category: Gileadi, O.]]
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[[Category: Hatzos C]]
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[[Category: Hatzos, C.]]
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[[Category: Joachimiak A]]
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[[Category: Joachimiak, A.]]
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[[Category: Johansson C]]
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[[Category: Johansson, C.]]
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[[Category: Kim Y]]
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[[Category: Kim, Y.]]
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[[Category: Knapp S]]
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[[Category: Knapp, S.]]
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[[Category: Muniz J]]
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[[Category: Muniz, J.]]
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[[Category: Savitsky P]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Vollmar M]]
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[[Category: Savitsky, P.]]
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[[Category: Weger A]]
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[[Category: Vollmar, M.]]
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[[Category: Weigelt J]]
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[[Category: Weger, A.]]
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[[Category: Von Delft F]]
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[[Category: Weigelt, J.]]
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[[Category: Alpha-beta-alpha sandwich]]
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[[Category: Cytosol]]
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[[Category: Hydrolase]]
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[[Category: Kinase]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 29 08:16:50 2010''
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Current revision

Crystal Structure of Cell Division Cycle 25C Protein Isoform A from Homo sapiens

PDB ID 3op3

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