1orl

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{{Seed}}
 
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[[Image:1orl.png|left|200px]]
 
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==1H NMR structure determination of Viscotoxin C1==
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The line below this paragraph, containing "STRUCTURE_1orl", creates the "Structure Box" on the page.
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<StructureSection load='1orl' size='340' side='right'caption='[[1orl]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1orl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ORL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ORL FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1orl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1orl OCA], [https://pdbe.org/1orl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1orl RCSB], [https://www.ebi.ac.uk/pdbsum/1orl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1orl ProSAT]</span></td></tr>
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{{STRUCTURE_1orl| PDB=1orl | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/THNC_VISAL THNC_VISAL]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/or/1orl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1orl ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The high resolution three-dimensional structure of the newly discovered plant viscotoxin C1, from the Asiatic Viscum album ssp. Coloratum ohwi, has been determined in solution by (1)H NMR spectroscopy at pH 3.6 and 285 K. The viscotoxin C1-fold, consisting of a helix-turn-helix motif and a short stretch of an antiparralel beta-sheet is very similar to that found for the highly similar viscotoxins A2 and A3 and for other related thionins. Different functional properties of members of the thionin family are discussed here in light of the structural and electrostatic properties. Among the very homologous family of alpha- and beta-thionins, known for their antimicrobial activity, the viscotoxin subfamily differs from the other members because of its high toxicity against tumoral cells. Key residues for the modulation of viscotoxin cytotoxicity have been identified on the basis of sequence and structural alignment.
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===1H NMR structure determination of Viscotoxin C1===
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NMR solution structure of viscotoxin C1 from Viscum album species Coloratum ohwi: toward a structure-function analysis of viscotoxins.,Romagnoli S, Fogolari F, Catalano M, Zetta L, Schaller G, Urech K, Giannattasio M, Ragona L, Molinari H Biochemistry. 2003 Nov 4;42(43):12503-10. PMID:14580196<ref>PMID:14580196</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_14580196}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1orl" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 14580196 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_14580196}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1ORL is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ORL OCA].
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==Reference==
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<ref group="xtra">PMID:14580196</ref><references group="xtra"/>
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[[Category: Viscum album]]
[[Category: Viscum album]]
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[[Category: Catalano, M.]]
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[[Category: Catalano M]]
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[[Category: Fogolari, F.]]
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[[Category: Fogolari F]]
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[[Category: Giannattasio, M.]]
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[[Category: Giannattasio M]]
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[[Category: Molinari, H.]]
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[[Category: Molinari H]]
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[[Category: Ragona, L.]]
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[[Category: Ragona L]]
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[[Category: Romagnoli, S.]]
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[[Category: Romagnoli S]]
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[[Category: Urech, K.]]
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[[Category: Urech K]]
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[[Category: Beta-sheet]]
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[[Category: Concentric motif of disulphide bridge]]
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[[Category: Helix-turn-helix]]
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[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 29 08:44:25 2010''
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Current revision

1H NMR structure determination of Viscotoxin C1

PDB ID 1orl

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