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3p0c
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3p0c is ON HOLD Authors: Schutz, P., Karlberg, T., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Nischarin PX-domain== | |
| - | + | <StructureSection load='3p0c' size='340' side='right'caption='[[3p0c]], [[Resolution|resolution]] 2.27Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3p0c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P0C FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.273Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p0c OCA], [https://pdbe.org/3p0c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p0c RCSB], [https://www.ebi.ac.uk/pdbsum/3p0c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p0c ProSAT]</span></td></tr> | |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NISCH_HUMAN NISCH_HUMAN] Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation (By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed (By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.<ref>PMID:10882231</ref> <ref>PMID:12868002</ref> <ref>PMID:15028619</ref> <ref>PMID:15028621</ref> <ref>PMID:15475348</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Berglund H]] | ||
| + | [[Category: Bountra C]] | ||
| + | [[Category: Collins R]] | ||
| + | [[Category: Edwards AM]] | ||
| + | [[Category: Flodin S]] | ||
| + | [[Category: Flores A]] | ||
| + | [[Category: Graslund S]] | ||
| + | [[Category: Hammarstrom M]] | ||
| + | [[Category: Johansson I]] | ||
| + | [[Category: Karlberg T]] | ||
| + | [[Category: Kol S]] | ||
| + | [[Category: Kotenyova T]] | ||
| + | [[Category: Kouznetsova E]] | ||
| + | [[Category: Moche M]] | ||
| + | [[Category: Nordlund P]] | ||
| + | [[Category: Nyman T]] | ||
| + | [[Category: Persson C]] | ||
| + | [[Category: Schuler H]] | ||
| + | [[Category: Schutz P]] | ||
| + | [[Category: Siponen MI]] | ||
| + | [[Category: Thorsell AG]] | ||
| + | [[Category: Tresaugues L]] | ||
| + | [[Category: Van Der Berg S]] | ||
| + | [[Category: Wahlberg E]] | ||
| + | [[Category: Weigelt J]] | ||
| + | [[Category: Welin M]] | ||
Current revision
Nischarin PX-domain
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Berglund H | Bountra C | Collins R | Edwards AM | Flodin S | Flores A | Graslund S | Hammarstrom M | Johansson I | Karlberg T | Kol S | Kotenyova T | Kouznetsova E | Moche M | Nordlund P | Nyman T | Persson C | Schuler H | Schutz P | Siponen MI | Thorsell AG | Tresaugues L | Van Der Berg S | Wahlberg E | Weigelt J | Welin M
