2kpy

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{{Seed}}
 
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[[Image:2kpy.jpg|left|200px]]
 
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==Solution Structure of the major allergen of Artemisia vulgaris (Art v 1)==
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The line below this paragraph, containing "STRUCTURE_2kpy", creates the "Structure Box" on the page.
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<StructureSection load='2kpy' size='340' side='right'caption='[[2kpy]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2kpy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Artemisia_vulgaris Artemisia vulgaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KPY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KPY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kpy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kpy OCA], [https://pdbe.org/2kpy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kpy RCSB], [https://www.ebi.ac.uk/pdbsum/2kpy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kpy ProSAT]</span></td></tr>
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{{STRUCTURE_2kpy| PDB=2kpy | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALL1_ARTVU ALL1_ARTVU]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The interaction of specific IgE antibodies with allergens is a key event in the induction of allergic symptoms, thus representing an important target for therapeutic interventions in Type I allergies. We report here the solution NMR structure of Art v 1, the major mugwort pollen allergen. Art v 1 is the first protein structure with an allergenic defensin fold linked to a polyproline domain, which has not been identified in any reported allergen structure in the PDB. Moreover, the direct interaction of polyclonal IgE antibodies from an allergic patient has been mapped on the surface of an allergen for the first time. The data presented herein provide the basis for the design of tools for safe and effective vaccination against mugwort pollen allergy.
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===Solution Structure of the major allergen of Artemisia vulgaris (Art v 1)===
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Mapping the interactions between a major pollen allergen and human IgE antibodies.,Razzera G, Gadermaier G, de Paula V, Almeida MS, Egger M, Jahn-Schmid B, Almeida FC, Ferreira F, Valente AP Structure. 2010 Aug 11;18(8):1011-21. PMID:20696401<ref>PMID:20696401</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_20696401}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2kpy" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20696401 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20696401}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2KPY is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Artemisia_vulgaris Artemisia vulgaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KPY OCA].
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==Reference==
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<ref group="xtra">PMID:20696401</ref><references group="xtra"/>
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[[Category: Artemisia vulgaris]]
[[Category: Artemisia vulgaris]]
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[[Category: Almeida, F.]]
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[[Category: Large Structures]]
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[[Category: Almeida, M.]]
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[[Category: Almeida F]]
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[[Category: Egger, M.]]
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[[Category: Almeida M]]
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[[Category: Ferreira, F.]]
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[[Category: Egger M]]
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[[Category: Gadermaier, G.]]
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[[Category: Ferreira F]]
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[[Category: Jahn-Schmid, B.]]
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[[Category: Gadermaier G]]
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[[Category: Razzera, G.]]
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[[Category: Jahn-Schmid B]]
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[[Category: Valente, A.]]
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[[Category: Razzera G]]
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[[Category: Allergen]]
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[[Category: Valente A]]
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[[Category: Defensin-like]]
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[[Category: Poly-proline]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 6 06:02:26 2010''
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Current revision

Solution Structure of the major allergen of Artemisia vulgaris (Art v 1)

PDB ID 2kpy

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