2jyd

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(New page: 200px<br /><applet load="2jyd" size="350" color="white" frame="true" align="right" spinBox="true" caption="2jyd" /> '''Structure of the fifth zinc finger of Myelin...)
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[[Image:2jyd.jpg|left|200px]]<br /><applet load="2jyd" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2jyd" />
 
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'''Structure of the fifth zinc finger of Myelin Transcription Factor 1'''<br />
 
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==Overview==
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==Structure of the fifth zinc finger of Myelin Transcription Factor 1==
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Zinc binding domains, or zinc fingers (ZnFs), form one of the most, numerous and most diverse superclasses of protein structural motifs in, eukaryotes. While our understanding of the functions of several classes of, these domains is relatively well developed, we know much less about the, molecular mechanisms of action of many others. Myelin transcription factor, 1 (MyT1) type ZnFs are found in organisms as diverse as nematodes and, mammals and are found in a range of sequence contexts. MyT1, one of the, early transcription factors expressed in the developing central nervous, system, contains seven MyT1 ZnFs that are very highly conserved both, within the protein and between species. We have used a range of, biophysical techniques, including NMR spectroscopy and data-driven, macromolecular docking, to investigate the structural basis for the, interaction between MyT1 ZnFs and DNA. Our data indicate that MyT1 ZnFs, recognize the major groove of DNA in a way that appears to differ from, other known zinc-binding domains.
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<StructureSection load='2jyd' size='340' side='right'caption='[[2jyd]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2jyd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JYD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jyd OCA], [https://pdbe.org/2jyd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jyd RCSB], [https://www.ebi.ac.uk/pdbsum/2jyd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jyd ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MYT1_MOUSE MYT1_MOUSE] Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription (By similarity).<ref>PMID:9373037</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/2jyd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jyd ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Zinc binding domains, or zinc fingers (ZnFs), form one of the most numerous and most diverse superclasses of protein structural motifs in eukaryotes. Although our understanding of the functions of several classes of these domains is relatively well developed, we know much less about the molecular mechanisms of action of many others. Myelin transcription factor 1 (MyT1) type ZnFs are found in organisms as diverse as nematodes and mammals and are found in a range of sequence contexts. MyT1, one of the early transcription factors expressed in the developing central nervous system, contains seven MyT1 ZnFs that are very highly conserved both within the protein and between species. We have used a range of biophysical techniques, including NMR spectroscopy and data-driven macromolecular docking, to investigate the structural basis for the interaction between MyT1 ZnFs and DNA. Our data indicate that MyT1 ZnFs recognize the major groove of DNA in a way that appears to differ from other known zinc binding domains.
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==About this Structure==
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Structural and biophysical analysis of the DNA binding properties of myelin transcription factor 1.,Gamsjaeger R, Swanton MK, Kobus FJ, Lehtomaki E, Lowry JA, Kwan AH, Matthews JM, Mackay JP J Biol Chem. 2008 Feb 22;283(8):5158-67. Epub 2007 Dec 11. PMID:18073212<ref>PMID:18073212</ref>
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2JYD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYD OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structural and biophysical analysis of the DNA-binding properties of myelin transcription factor 1., Gamsjaeger R, Swanton MK, Kobus FJ, Lehtomaki E, Lowry JA, Kwan AH, Matthews JM, Mackay JP, J Biol Chem. 2007 Dec 11;. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18073212 18073212]
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</div>
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<div class="pdbe-citations 2jyd" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Gamsjaeger R]]
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[[Category: Gamsjaeger, R.]]
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[[Category: Kobus FJ]]
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[[Category: Kobus, F.J.]]
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[[Category: Kwan AH]]
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[[Category: Kwan, A.H.]]
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[[Category: Lehtomaki E]]
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[[Category: Lehtomaki, E.]]
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[[Category: Lowry JA]]
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[[Category: Lowry, J.A.]]
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[[Category: Mackay JP]]
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[[Category: Mackay, J.P.]]
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[[Category: Matthews JM]]
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[[Category: Matthews, J.M.]]
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[[Category: Swanton MK]]
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[[Category: Swanton, M.K.]]
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[[Category: ZN]]
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[[Category: alternative splicing]]
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[[Category: developmental protein]]
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[[Category: differentiation]]
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[[Category: dna-binding]]
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[[Category: metal binding protein]]
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[[Category: metal-binding]]
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[[Category: myt1]]
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[[Category: neurogenesis]]
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[[Category: nucleus]]
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[[Category: transcription]]
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[[Category: transcription regulation]]
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[[Category: zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 11:05:48 2008''
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Current revision

Structure of the fifth zinc finger of Myelin Transcription Factor 1

PDB ID 2jyd

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