3ojf

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{{Seed}}
 
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[[Image:3ojf.png|left|200px]]
 
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==Crystal Structure of the Bacillus cereus Enoyl-Acyl Carrier Protein Reductase with NADP+ and indole naphthyridinone (Complex form)==
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The line below this paragraph, containing "STRUCTURE_3ojf", creates the "Structure Box" on the page.
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<StructureSection load='3ojf' size='340' side='right'caption='[[3ojf]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ojf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_cereus_ATCC_14579 Bacillus cereus ATCC 14579]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OJF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OJF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMJ:(2E)-N-[(1,2-DIMETHYL-1H-INDOL-3-YL)METHYL]-N-METHYL-3-(7-OXO-5,6,7,8-TETRAHYDRO-1,8-NAPHTHYRIDIN-3-YL)PROP-2-ENAMIDE'>IMJ</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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{{STRUCTURE_3ojf| PDB=3ojf | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ojf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ojf OCA], [https://pdbe.org/3ojf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ojf RCSB], [https://www.ebi.ac.uk/pdbsum/3ojf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ojf ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FABI_BACCR FABI_BACCR] Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oj/3ojf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ojf ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Enoyl-[acyl carrier protein] reductase (ENR) is an essential enzyme in type II fatty-acid synthesis that catalyzes the last step in each elongation cycle. Thus far FabI, FabL and FabK have been reported to carry out the reaction, with FabI being the most characterized. Some bacteria have more than one ENR, and Bacillus cereus has two (FabI and FabL) reported. Here, we have determined the crystal structures of the later in the apo form and in the ternary complex with NADP(+) and an indole naphthyridinone inhibitor. The two structures are almost identical, except for the three stretches that are disordered in the apo form. The apo form exists as a homo-dimer in both crystal and solution, while the ternary complex forms a homo-tetramer. The three stretches disordered in the apo structure are important in the cofactor and the inhibitor binding as well as in tetramer formation.
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===Crystal Structure of the Bacillus cereus Enoyl-Acyl Carrier Protein Reductase with NADP+ and indole naphthyridinone (Complex form)===
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Dimeric and tetrameric forms of enoyl-acyl carrier protein reductase from Bacillus cereus.,Kim SJ, Ha BH, Kim KH, Hong SK, Shin KJ, Suh SW, Kim EE Biochem Biophys Res Commun. 2010 Oct 1;400(4):517-22. Epub 2010 Aug 26. PMID:20800575<ref>PMID:20800575</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3ojf" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_20800575}}, adds the Publication Abstract to the page
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*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 20800575 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20800575}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Bacillus cereus ATCC 14579]]
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3OJF is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OJF OCA].
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[[Category: Large Structures]]
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[[Category: Ha BH]]
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==Reference==
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[[Category: Hong SK]]
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<ref group="xtra">PMID:20800575</ref><references group="xtra"/>
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[[Category: Kim EE]]
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[[Category: Bacillus cereus]]
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[[Category: Kim KH]]
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[[Category: Ha, B H.]]
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[[Category: Kim SJ]]
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[[Category: Hong, S K.]]
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[[Category: Suh SW]]
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[[Category: Kim, E E.]]
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[[Category: Kim, K H.]]
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[[Category: Kim, S J.]]
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[[Category: Suh, S W.]]
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[[Category: Enoyl-acp reductase]]
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[[Category: Oxidoreductase]]
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[[Category: Rossmann fold]]
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[[Category: Tetramer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 13 10:22:36 2010''
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Current revision

Crystal Structure of the Bacillus cereus Enoyl-Acyl Carrier Protein Reductase with NADP+ and indole naphthyridinone (Complex form)

PDB ID 3ojf

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