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3ory
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Flap endonuclease 1 from hyperthermophilic archaeon Desulfurococcus amylolyticus== | |
| + | <StructureSection load='3ory' size='340' side='right'caption='[[3ory]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3ory]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Desulfurococcus_amylolyticus Desulfurococcus amylolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ORY FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ory FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ory OCA], [https://pdbe.org/3ory PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ory RCSB], [https://www.ebi.ac.uk/pdbsum/3ory PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ory ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/F2Z289_DESAM F2Z289_DESAM] Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.[HAMAP-Rule:MF_00614] | ||
| - | + | ==See Also== | |
| - | + | *[[Endonuclease 3D structures|Endonuclease 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Desulfurococcus amylolyticus]] | |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kawarabayashii Y]] | ||
| + | [[Category: Kubota K]] | ||
| + | [[Category: Mase T]] | ||
| + | [[Category: Miyazono K]] | ||
| + | [[Category: Tanokura M]] | ||
Current revision
Crystal structure of Flap endonuclease 1 from hyperthermophilic archaeon Desulfurococcus amylolyticus
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