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3ozo
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with NGT== | |
| + | <StructureSection load='3ozo' size='340' side='right'caption='[[3ozo]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3ozo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ostrinia_furnacalis Ostrinia furnacalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OZO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OZO FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NGT:3AR,5R,6S,7R,7AR-5-HYDROXYMETHYL-2-METHYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D]THIAZOLE-6,7-DIOL'>NGT</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ozo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ozo OCA], [https://pdbe.org/3ozo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ozo RCSB], [https://www.ebi.ac.uk/pdbsum/3ozo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ozo ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HEXC_OSTFU HEXC_OSTFU] Hydrolyzes one beta-GlcNAc unit at a time from the non-reducing ends of substrates, with a preference for shorter substrates. The 2-acetamido group and the beta-glycoside bond linkage in the substrate are required for its activity. Active with p-nitrophenyl (pNP)-beta-GlcNAc, pNP-beta-GalNAc and chitooligosaccharides (degree of polymerization from 2 to 6), but not with the complex N-glycan substrate (GlcNAcbeta-1,2Manalpha-1,6)(GlcNAcbeta-1,2Manalpha-1,3)Manbeta-1,4GlcNAcbeta-1,4GlcNAc-PA (GnGn-PA), pNP-alpha-GlcNAc or with the long polymer colloidal chitin. Involved in chitin catabolism (PubMed:18959754). Involved in the degradation of old cuticle during the pupation stage (PubMed:21106526).<ref>PMID:18959754</ref> <ref>PMID:21106526</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Beta-Hexosaminidase|Beta-Hexosaminidase]] | |
| - | + | *[[Beta-Hexosaminidase 3D structures|Beta-Hexosaminidase 3D structures]] | |
| - | + | *[[Beta-N-acetylhexosaminidase 3D structures|Beta-N-acetylhexosaminidase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ostrinia furnacalis]] | ||
| + | [[Category: Liu F]] | ||
| + | [[Category: Liu T]] | ||
| + | [[Category: Shen X]] | ||
| + | [[Category: Yang Q]] | ||
| + | [[Category: Zhang H]] | ||
Current revision
Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with NGT
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Categories: Large Structures | Ostrinia furnacalis | Liu F | Liu T | Shen X | Yang Q | Zhang H
